Antibodies Inc

Gs Protein/Alpha Subunit Monoclonal Antibody (N192/12), FL594

Name: Gs Protein\/Alpha Subunit Monoclonal Antibody (N192\/12), FL594
Brand: Antibodies Inc
SKU: 75-211-FL594

查看其他24个GNAS抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image Gs Protein/Alpha Subunit Monoclonal Antibody (N192/12), FL594

产品信息

75-211-FL594

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent

酶联免疫吸附实验 (ELISA)

Assay-dependent

产品规格

种属反应

Bovine, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

N192/12

抗原

Fusion protein amino acids 1-380 (full-length, short form) of bovine Gs protein alpha subunit (accession number P04896-2) produced recombinantly in E. Coli.

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偶联物

FL594 FL594 FL594

激发/发射光谱

594/615 nm

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Dry ice (international)

产品详细信息

For maximum recovery of product, centrifuge the vial prior to removing the cap.

靶标信息

Mutations in GNAS gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseous heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. This gene has a highly complex imprinted expression pattern. It encodes maternally, paternally, and biallelically expressed proteins which are derived from alternatively spliced transcripts with alternate 5' exons. Each of the upstream exons is within a differentially methylated region, commonly found in imprinted genes. However, the close proximity (14 kb) of two oppositely expressed promoter regions is unusual. In addition, one of the alternate 5' exons introduces a frameshift relative to the other transcripts, resulting in one isoform which is structurally unrelated to the others. An antisense transcript exists, and may regulate imprinting in this region. Mutations in this gene result in pseudohypoparathyroidism type 1a (PHP1a), which has an atypical autosomal dominant inheritance pattern requiring maternal transmission for full penetrance.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Adenylate cyclase-stimulating G alpha protein; Alternative gene product encoded by XL-exon; dJ309F20.1.1; dJ806M20.3.3; Extra large alphas protein; G protein alpha subunit; G-alpha-8; GNAS; GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus; gnas {ECO:0000312|RGD:2716}; Gs alpha subunit; GTP-binding regulatory protein (G-s-alpha).; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide binding protein alpha s; guanine nucleotide-binding protein G(s) subunit alpha isoforms; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; guanine nucleotide-binding protein G-s, alpha subunit; MGC33735; NESP55; Neuroendocrine secretory protein 55; OTTHUMP00000031742; OTTHUMP00000196026; OTTHUMP00000196030; PHP1C; Protein ALEX; RP4-543J19.4; secretogranin VI; stimulatory G-protein alpha subunit; unnamed protein product; XLalphas; XLas

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基因别名: 5530400H20Rik; A930027G11Rik; C130027O20Rik; Galphas; GNAS; GNAS1; Gnasxl; Gnpas; GPSA; Gsa; GSP; MNCb-5546; Nesp; NESP55; Nespl; Oed-Sml; Oedsml; P1; P2; P3; PHP1A; PHP1B; POH; SCG6

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UniProt ID: (Bovine) P04896, (Mouse) Q6R0H6, (Rat) P63095

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Entrez Gene ID: (Bovine) 281793, (Mouse) 14683, (Rat) 24896

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