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Invitrogen
H2BR17me1 Recombinant Rabbit Monoclonal Antibody (K01_4P08)
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产品信息
MA567509
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4P08
抗原
A synthesized peptide derived from human Histone H2B (mono methyl K116).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA, 150mM NaCl, 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
H2BR17me1 refers to the monomethylation of arginine 17 on histone H2B, an epigenetic modification that affects chromatin architecture and transcriptional regulation rather than a gene product itself. Histone H2B is encoded by multiple H2B genes, for example members of the HIST1H2B family, and the R17 residue can be methylated by protein arginine methyltransferases, while demethylating enzymes or deimination can alter this state. H2BR17me1 is implicated in fine tuning nucleosome dynamics, transcriptional initiation and elongation, and may participate in pathways related to cell differentiation and stress responses, although its specific writers, erasers, and readers are less comprehensively defined than those for more established histone marks. Detection commonly uses mass spectrometry and modification specific antibodies in ChIP based assays to profile genomic distribution. Overall, H2BR17me1 is best considered a histone modification target, with ongoing research to clarify its biological roles and regulatory mechanisms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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