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Invitrogen
H3K28ac Recombinant Rabbit Monoclonal Antibody (16A13)
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图: 1 / 20
H3K28ac Antibody (MA573249) in ICC/IF
Immunocytochemistry analysis of H3K28ac in SH-SY5Y cells. Permeabilized with Trinton X-100 at room temp for 20 min. Samples were incubated with H3K28ac Recombinant Monoclonal (Product # MA573249 using a dilution at 1:100, for 90 min at 37°C. Followed by conjugated Goat Anti-Rabbit IgG antibody (green) at 37°C for 90 min, DAPI was used to stain the cell nuclei. PBS instead of the primary antibody was used as the blank control.
产品信息
MA573249
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
16A13
抗原
KLH conjugated synthetic peptide derived from human Histone H3.1 around the acetylation site of K28.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
规格
40 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
H3K28ac refers to acetylation of lysine 28 on histone H3, a post translational modification catalyzed by histone acetyltransferases (HATs) and reversed by histone deacetylases (HDACs). This acetylation reduces the positive charge on the lysine residue, weakening histone DNA interactions and promoting a more open chromatin structure that facilitates access of transcription factors and RNA polymerase, thereby supporting transcriptional activation. Biologically, H3K28ac is enriched at promoters and enhancers of actively transcribed genes and serves as a marker of regulatory regions involved in gene expression, cellular differentiation, development, and responses to environmental signals. Clinically, abnormal H3K28ac patterns are associated with diseases such as cancer, where dysregulated acetylation contributes to altered gene expression, making H3K28ac a potential biomarker and positioning HATs and HDACs as therapeutic targets, with inhibitors under investigation for treating acetylation related disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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