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Invitrogen
HAP40 Recombinant Rabbit Monoclonal Antibody (HL2642)
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HAP40 Antibody (MA5-56734) in WB
Western Blot analysis of HAP40 using HAP40 Recombinant Monoclonal Antibody (Product # MA5-56734). 293T, A431, HeLa, and HepG2 whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with HAP40 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-56734
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2642
抗原
Synthetic peptide of human HAP40
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
Huntington's disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the Huntington protein. Huntington co-purifies with a single novel 40 kDa protein designated HAP40. Recombinant HAP40 is cytoplasmic in the presence of Huntington but is actively targeted to the nucleus in the absence of Huntington. These observations suggest that HAP40 °Contributes to the function of normal Huntington and is a candidate for involvement in the aberrant nuclear localization of mutant Huntington found in degenerating neurons in Huntington's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 40-kDa huntingtin-associated protein; coagulation factor VIII-associated (intronic transcript) 1; CpG island protein; factor 8-associated gene A; Factor VIII associated protein; Factor VIII intron 22 protein; HAP40; huntingtin-associated protein 40; RP23-114O19.4
基因别名: AI852759; DXUcsf1; F8a; F8A1; F8A2; F8A3; Hap40; RGD1566014
UniProt ID: (Mouse) Q00558, (Rat) M0RDU0
Entrez Gene ID: (Mouse) 14070, (Rat) 501661
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