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Abnova
HAPLN4 Monoclonal Antibody (1G5)
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产品信息
H00404037-M12
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG3, kappa
分类
Monoclonal
类型
Antibody
克隆号
1G5
抗原
HAPLN4 (NP_075378, 30 a.a. approximately 134 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
Immunogen sequence: QRGRKKVVHV LEGESGSVVV QTAPGQVVSH RGGTIVLPCR YHYEAAAHGH DGVRLKWTKV VDPLAFTDVF VALGPQHRAF GSYRGRAELQ GDGPGDASLV LRNVT
靶标信息
Hyaluronan and proteoglycan link protein 4 (HAPLN4), also known as Brain Link Protein 4 (BRAL1), is a gene located on chromosome 5q14.2, encoding a member of the link protein family that plays a crucial role in stabilizing interactions between hyaluronan and proteoglycans within the extracellular matrix. HAPLN4 is predominantly expressed in the brain, especially within the central nervous system where it contributes to the structural integrity and functional modulation of neural tissues. The protein is key in maintaining the organization of the extracellular matrix by binding hyaluronan and other matrix components, facilitating cell adhesion and signaling. This is vital for processes like neuronal migration, synapse formation, and neuronal differentiation during brain development. Variations in HAPLN4 expression or function are associated with neural developmental disorders and may influence the progression of neurodegenerative diseases due to its critical role in preserving the extracellular matrix architecture and neural connectivity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Brain link protein 2; brain linked protein 2; Hyaluronan and proteoglycan link protein 4; link protein 4
基因别名: 9330174O11; BRAL2; HAPLN4; KIAA1926; Lpr4
UniProt ID: (Human) Q86UW8, (Mouse) Q80WM4
Entrez Gene ID: (Human) 404037, (Mouse) 330790
