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This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
Immunogen sequence: KFKINKQHAR RVYEILRLLV TDMSDAEQYR SYRLDIKRRL ISPYKKKQRD LAKMRKCLRP EELTNQMNQI EISMQHEQLE ESFQELVEDY RRVIERLA
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: histidine aminotransferase 1; Histone acetyltransferase 1; Histone acetyltransferase type B catalytic subunit; histone aminotransferase 1
基因别名: 2410071B14Rik; AA536933; Hat-1; HAT1; KAT1
UniProt ID: (Human) O14929, (Mouse) Q8BY71, (Rat) Q5M939
Entrez Gene ID: (Human) 8520, (Mouse) 107435, (Rat) 296501
分子生物学功能: histone modifying enzyme