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Invitrogen
HCLS1 Polyclonal Antibody
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FIGURE: 1 / 2
HCLS1 Antibody (PA5-102594) in WB
Western blot was performed using HCLS1 Polyclonal Antibody (Product # PA5-102594) and a 70 kDa band corresponding to HCLS1 was observed. Whole cell extracts (30 µg lysate) of NK-92 (Lane 1), Jurkat (Lane 2), THP-1 (Lane 3), HeLa (Lane 4), SK-O-V3 (Lane 5) and Hep G2 (Lane 6) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX), 12 well. Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the pr... View More
Product Details
PA5-102594
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human HCLS1(Accession P14317), corresponding to amino acid residues L173-K223.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total HCLS1.
Target Information
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hematopoietic cell-specific LYN substrate 1; Hematopoietic lineage cell-specific protein; LckBP1; p75
Gene Aliases: AW213261; CTTNL; HCLS1; HS1; lckBP1; p75
UniProt ID: (Human) P14317, (Mouse) Q922I8
Entrez Gene ID: (Human) 3059, (Mouse) 15163, (Rat) 288077
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
positive regulation of cell proliferation
response to hormone
positive regulation of phosphatidylinositol 3-kinase signaling
actin filament polymerization
erythrocyte differentiation
regulation of actin filament polymerization
positive regulation of granulocyte differentiation
positive regulation of peptidyl-serine phosphorylation
intracellular signal transduction
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of transcription factor import into nucleus
positive regulation of macrophage differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
negative regulation of leukocyte apoptotic process
positive regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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