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Invitrogen
HCMV US28 VHH-His Recombinant Alpaca Monoclonal Antibody (Iv0102)
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产品信息
MA562848
产品规格
种属反应
Virus
宿主/亚型
Alpaca
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Iv0102
抗原
Recombinant HCMV US28 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Metal-chelate chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
HCMV US28 is a viral chemokine receptor encoded by the Human Cytomegalovirus (HCMV) classified among the seven-transmembrane G-protein-coupled receptors with constitutive ligand-independent signaling activity. This receptor is known for its ability to bind a broad range of chemokines including both CC and CX_3C motifs facilitating viral immune evasion and cell-cell adhesion processes. US28 plays a significant role in HCMV pathogenesis contributing to viral persistence and influencing the transcriptional regulation of oncogenic pathways within infected cells. The receptor's constitutive activation results in hijacked cellular signaling pathways that promote cell proliferation and survival making US28 a target of interest in therapeutic research for combating HCMV-associated disorders including cardiovascular diseases and cancers. Understanding its structure and function has crucial implications in the development of antiviral strategies aimed at disrupting HCMV signaling and infection mechanisms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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