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Antibodies Inc
HCN4 Monoclonal Antibody (N114/10), FL550
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Product Details
75-150-FL550
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Gerbil,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N114/10
Immunogen
Fusion protein amino acids 1019-1108 (cytoplasmic C-terminus) of rat HCN4 (accession number Q9JKA7) produced recombinantly in E. Coli.
Conjugate
Excitation/Emission Max
550/575 nm
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
HCN4 is a member of the family of hyperpolarization-activated and cyclic-nucleotide-gated (HCN) channels. HCN currents have been linked to pacemaker activity in the heart and brain, resting potential control, as well as neuronal plasticity. It has been shown that HCN4 channels function as receptors for sour taste, and are associated with pacemaker potential generation in the sinoatrial node.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCNG-3; Brain cyclic nucleotide-gated channel 3; hyperpolarization activated cyclic nucleotide-gated cation channel 4; hyperpolarization activated cyclic nucleotide-gated potassium channel 4; hyperpolarization-activated, cyclic nucleotide-gated K+ 3; hyperpolarization-activated, cyclic nucleotide-gated K+ 4; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Aliases: Bcng3; Hcn3; HCN4; SSS2
UniProt ID: (Human) Q9Y3Q4, (Mouse) O70507, (Rat) Q9JKA7
Entrez Gene ID: (Pig) 100156534, (Human) 10021, (Mouse) 330953, (Rat) 59266
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
cAMP binding
identical protein binding
nucleotide binding
ion channel activity
voltage-gated ion channel activity
potassium channel activity
sodium channel activity
protein binding
ion channel
transporter
regulation of heart rate
regulation of membrane depolarization
cation transport
muscle contraction
blood circulation
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
regulation of cardiac muscle contraction
regulation of postsynaptic membrane potential
cellular response to cAMP
cellular response to cGMP
potassium ion transmembrane transport
SA node cell action potential
regulation of heart rate by cardiac conduction
in utero embryonic development
transport
ion transport
potassium ion transport
sodium ion transport
regulation of heart contraction
transmembrane transport
cation transmembrane transport
modulation of synaptic transmission
cellular response to steroid hormone stimulus
response to cisplatin
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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