Search
Agrisera
HDA6/Histone deacetylase 6 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
AS14-2787
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated synthetic peptide chosen from HDA6 protein of Arabidopsis thaliana. Peptide used for immunization is not conserved in HDA9 of Arabidopsis thaliana.
偶联物
形式
Lyophilized
规格
50 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
靶标信息
HDA6 encodes a RPD3-type (class I) histone deacetylase in Arabidopsis thaliana that is predominantly nuclear and is enriched in discrete nuclear subdomains including the nucleolus, consistent with roles in rDNA-associated chromatin regulation. The encoded protein is a ~471 amino-acid enzyme containing a conserved histone deacetylase catalytic domain typical of RPD3/HDAC family members, enabling removal of acetyl groups from lysine residues on histone H3/H4 tails and thereby promoting chromatin compaction. Functionally, HDA6 acts as a key epigenetic repressor that helps maintain transcriptional silencing of repetitive loci, including rDNA repeats and transposable elements, with loss of HDA6 leading to localized histone hyperacetylation, altered histone methylation patterns, chromatin decondensation, and transcriptional derepression. Mechanistically, HDA6 cooperates with DNA methylation pathways, including direct interaction with the maintenance CG methyltransferase MET1, linking histone deacetylation to the establishment/maintenance of heterochromatic DNA methylation states and stable genome-wide repression of silenced loci.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: ATHDA6; AXE1; HDAC6; HISTONE DEACETYLASE 6; RNA-MEDIATED TRANSCRIPTIONAL SILENCING 1; RPD3B; RTS1; SIL1
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
