Invitrogen

HDAC1 Polyclonal Antibody

查看其他38个HDAC1抗体

问题与答案

问题与答案

问题与答案

Additional Information:

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抗体检测数据 (7)

HDAC1 Antibody in Immunocytochemistry (ICC/IF)

HDAC1 Antibody in Immunocytochemistry (ICC/IF)

图: 1 / 7

HDAC1 Antibody (PA5150995) in ICC/IF

Immunocytochemistry analysis of HDAC1 using human cell line U-2 OS (shows localization to nucleoplasm). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Immunocytochemistry (ICC/IF)

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

HDAC1 Antibody in Western Blot (WB)

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HDAC1 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry analysis of HDAC1 using human cell line U-2 OS (shows localization to nucleoplasm). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of HDAC1 using paraffin-embedded human tonsil and skeletal muscle tissues. Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of HDAC1 using paraffin-embedded human small intestine (shows moderate nuclear positivity in glandular cells). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of HDAC1 using paraffin-embedded human fallopian tube (shows moderate nuclear positivity in glandular cells). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of HDAC1 using paraffin-embedded human tonsil (shows moderate nuclear positivity in germinal center cells). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry analysis of HDAC1 using paraffin-embedded human skeletal muscle (shows no positivity in myocytes). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

HDAC1 Antibody in Western Blot (WB) — Western blot analysis of HDAC1 using RT-4 cells transfected with control siRNA, target specific siRNA probe #1 and #2 (Loading control: Anti-GAPDH). Samples were incubated with HDAC1 polyclonal antibody (Product # PA5150995).

Immunogen image

HDAC1 Polyclonal Antibody

Immunogen Image HDAC1 Polyclonal Antibody

产品信息

PA5150995

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

-

免疫组化（石蜡） (IHC (P))

1:200-1:500

-

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein fragment of Human HDAC1 (Product # RP-95336).

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.2 mg/mL

20 µg

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Highest antigen sequence identity to the following orthologs: Mouse- 98%, Rat- 98%.

Sequence of this protein is as follows: RIACEEEFSD SEEEGEGGRK NSSNFKKAKR VKTEDEKEKD PEEKKEVTEE EKTKEEKPEA KGVKE

靶标信息

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp686H12203; HD1; HDAC1; Histone deacetylase 1; Protein deacetylase HDAC1; Protein deacylase HDAC1; protein decrotonylase HDAC1; reduced potassium dependency, yeast homolog-like 1; RP4-811H24.2; unnamed protein product

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基因别名: GON-10; HD1; HDAC1; KDAC1; RPD3; RPD3L1

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UniProt ID: (Human) Q13547

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Entrez Gene ID: (Human) 3065

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transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding core promoter sequence-specific DNA binding transcription corepressor binding p53 binding DNA binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides enzyme binding nucleosomal DNA binding protein deacetylase activity Krueppel-associated box domain binding histone deacetylase binding metal ion binding NF-kappaB binding RNA polymerase II sequence-specific DNA binding transcription factor binding E-box binding DNA-binding transcription factor binding histone deacetylase activity, hydrolytic mechanism protein decrotonylase activity histone decrotonylase activity protein lysine delactylase activity promoter-specific chromatin binding

negative regulation of transcription from RNA polymerase II promoter chromatin organization chromatin remodeling methylation-dependent chromatin silencing regulation of transcription from RNA polymerase II promoter protein deacetylation endoderm development circadian rhythm positive regulation of cell proliferation epidermal cell differentiation positive regulation of gene expression negative regulation of gene expression negative regulation of myotube differentiation hippocampus development neuron differentiation negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway heterochromatin assembly circadian regulation of gene expression positive regulation of intracellular estrogen receptor signaling pathway cellular response to platelet-derived growth factor stimulus odontogenesis of dentin-containing tooth regulation of cell fate specification embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation by host of viral transcription negative regulation of gene expression, epigenetic negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process positive regulation of smooth muscle cell proliferation oligodendrocyte differentiation positive regulation of oligodendrocyte differentiation negative regulation of androgen receptor signaling pathway hair follicle placode formation eyelid development in camera-type eye fungiform papilla formation negative regulation of canonical Wnt signaling pathway negative regulation of stem cell population maintenance positive regulation of stem cell population maintenance regulation of stem cell differentiation negative regulation of intrinsic apoptotic signaling pathway