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Invitrogen
HDAC2 Recombinant Rabbit Monoclonal Antibody (SY29-02)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-32101
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SY29-02
抗原
Synthetic peptide within Human HDAC2 aa 439-488.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
HDAC2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HD2; hdac 2; hdac-2; Histone deacetylase 2; Protein deacylase HDAC2; YY1 transcription factor-binding protein
基因别名: D10Wsu179e; HDAC2; mRPD3; YAF1; Yy1bp
UniProt ID: (Mouse) P70288
Entrez Gene ID: (Mouse) 15182, (Rat) 84577
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
core promoter binding
RNA polymerase II repressing transcription factor binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
histone deacetylase activity
protein binding
transcription factor binding
hydrolase activity
deacetylase activity
enzyme binding
heat shock protein binding
histone deacetylase activity (H3-K14 specific)
chromatin DNA binding
nucleosomal DNA binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
protein deacetylase activity
histone deacetylase activity (H4-K16 specific)
Krueppel-associated box domain binding
sequence-specific DNA binding
poly(A) RNA binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NF-kappaB binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
negative regulation of transcription from RNA polymerase II promoter
maintenance of chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
protein deacetylation
positive regulation of cell proliferation
epidermal cell differentiation
positive regulation of epithelial to mesenchymal transition
positive regulation of receptor biosynthetic process
negative regulation of neuron projection development
dendrite development
chromatin modification
histone deacetylation
hippocampus development
neuron differentiation
positive regulation of interleukin-1 production
positive regulation of tumor necrosis factor production
circadian regulation of gene expression
odontogenesis of dentin-containing tooth
positive regulation of tyrosine phosphorylation of Stat3 protein
embryonic digit morphogenesis
ATP-dependent chromatin remodeling
negative regulation of apoptotic process
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
positive regulation of oligodendrocyte differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
regulation of protein kinase B signaling
cardiac muscle cell development
negative regulation of cardiac muscle cell proliferation
regulation of sarcomere organization
hair follicle placode formation
negative regulation of dendritic spine development
eyelid development in camera-type eye
fungiform papilla formation
cellular response to hydrogen peroxide
histone H3 deacetylation
histone H4 deacetylation
negative regulation of canonical Wnt signaling pathway
regulation of protein deacetylation
negative regulation of peptidyl-lysine acetylation
negative regulation of intrinsic apoptotic signaling pathway
response to amphetamine
cardiac muscle hypertrophy
response to caffeine
response to lipopolysaccharide
cellular response to heat
response to nicotine
response to cocaine
response to drug
behavioral response to ethanol
response to hyperoxia
histone H3-K9 modification
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
cellular response to dopamine
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