Invitrogen

HDAC4 Recombinant Rabbit Monoclonal Antibody (23GB865)

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HDAC4 Recombinant Rabbit Monoclonal Antibody (23GB865)

产品信息

MA5-54010

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

免疫细胞化学 (ICC/IF)

1:1,000
-

流式细胞分析 (Flow)

1:2,000
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

23GB865

抗原

A synthetic peptide of human HDAC4 (30-100AA).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3248481

靶标信息

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: DKFZp779K1053; HD4; HD7; HD7b; HD9; HDAC; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 4; histone deacetylase A; KIAA0744; MITR

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基因别名: AHO3; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288

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UniProt ID: (Human) P56524

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Entrez Gene ID: (Human) 9759

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功能
RNA polymerase III transcription factor binding core promoter binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding zinc ion binding protein kinase binding potassium ion binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity activating transcription factor binding histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding histone modifying enzyme
参与通路
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast development chromatin remodeling transcription, DNA-templated inflammatory response nervous system development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of lamellipodium assembly negative regulation of myotube differentiation regulation of cardiac muscle contraction by calcium ion signaling response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress positive regulation of smooth muscle cell migration chromatin modification histone deacetylation B cell differentiation positive regulation of protein sumoylation peptidyl-lysine deacetylation regulation of gene expression, epigenetic B cell activation response to drug regulation of protein binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of osteoblast differentiation negative regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of sequence-specific DNA binding transcription factor activity response to interleukin-1 histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus positive regulation of reactive oxygen species biosynthetic process
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