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Rockland
HDAC5 (internal) Polyclonal Antibody
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HDAC5 (internal) Antibody (600-401-J69) in IHC (P)
Immunohistochemistry of Rabbit anti-HDAC5 antibody. Tissue: Colon. Fixation: formalin fixed paraffin embedded. Antigen retrieval: not required. Primary antibody: HDAC5 antibody at 5 µg/mL for 1 h at RT. Secondary antibody: Peroxidase rabbit secondary antibody at 1:10,000 for 45 min at RT. Staining: HDAC5 as precipitated red signal with hematoxylin purple nuclear counterstain.
产品信息
600-401-J69
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Anti-HDAC5 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the internal region surrounding 325-375aa of human HDAC5 protein.
偶联物
形式
Liquid
浓度
1.1 mg/mL
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl, 30% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
A BLAST analysis was used to suggest cross-reactivity with human and hamster based on 100% sequence homology. Cross-reactivity with HDAC5 from other sources has not been determined.
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Antigen NY-CO-9; DKFZp779K1053; FLJ90614; HD5; HD7; HD7b; HD9; HDAC; HDAC-5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDRP; Histone deacetylase 5; KIAA0744
基因别名: HD5; HDAC5; KIAA0600; NY-CO-9
UniProt ID: (Human) Q9UQL6
Entrez Gene ID: (Human) 10014
RNA polymerase III transcription factor binding
core promoter binding
chromatin binding
histone deacetylase activity
protein kinase C binding
protein binding
transcription factor binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
histone deacetylase binding
transcription regulatory region DNA binding
metal ion binding
repressing transcription factor binding
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
chromatin silencing
transcription, DNA-templated
protein deacetylation
inflammatory response
regulation of myotube differentiation
negative regulation of myotube differentiation
response to activity
chromatin modification
histone deacetylation
neuron differentiation
B cell differentiation
cellular response to insulin stimulus
regulation of gene expression, epigenetic
B cell activation
response to cocaine
response to drug
regulation of protein binding
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
histone H3 deacetylation
cellular response to lipopolysaccharide
negative regulation of cell migration involved in sprouting angiogenesis
regulation of histone H3-K9 acetylation
