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Invitrogen
HDAC7 Polyclonal Antibody
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HDAC7 Antibody (PA5-68836) in WB
Western blot was performed using Anti-HDAC7 Polyclonal Antibody (Product # PA5-68836) and a 102 kDa band corresponding to HDAC7 was observed in Mouse Brain and Rat Brain. Tissue extracts (30 µg lysate) of Mouse Brain (Lane 1) and Rat Brain (Lane 2) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000 dilution) and... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-68836
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the N-terminal region of rat HDAC7
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This target displays homology in the following species: Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 93%; Human: 93%; Mouse: 100%; Rat: 100%
靶标信息
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HD7; HD7a; hdac-7; histone deacetylase 7; histone deacetylase 7A
基因别名: Hdac7a
Entrez Gene ID: (Rat) 84582
molecular_function
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein kinase C binding
transcription factor binding
protein kinase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
activating transcription factor binding
metal ion binding
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
repressing transcription factor binding
14-3-3 protein binding
NAD-dependent histone deacetylase activity (H3-K18 specific)
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
vasculogenesis
chromatin organization
transcription, DNA-templated
regulation of transcription, DNA-templated
inflammatory response
cell-cell junction assembly
nervous system development
chromatin modification
histone deacetylation
neuron differentiation
B cell differentiation
negative regulation of interleukin-2 production
B cell activation
negative regulation of osteoblast differentiation
negative regulation of striated muscle tissue development
negative regulation of transcription, DNA-templated
neuron apoptotic process
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
cellular response to mechanical stimulus
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of neuron death
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