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HEY1 Antibody (PA5-23484) in WB
Western blot analysis of HEY1 in mouse embryo brain lysate using 1) preimmune sera at 1:5000 dilution and 2) purified antibody. Samples were incubated in HEY1 polyclonal antibody (Product # PA5-23484) followed by a goat anti-rabbit Ig HRP secondary antibody. PicoTect ECL substrate solution was used for this test.
产品信息
PA5-23484
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 50-100 of mouse Hey1
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2540984
靶标信息
Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hairy and enhancer of split-related protein 1; hairy-related transcription factor 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif protein 1; HRT-1; MGC1274; mHRT1
基因别名: AI316788; AI414254; bHLHb31; CHF2; Herp2; hesr-1; Hesr1; HRT1
Entrez Gene ID: (Mouse) 15213
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcription factor activity, protein binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
microsatellite binding
sequence-specific DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
vasculogenesis
osteoblast development
outflow tract morphogenesis
atrioventricular valve morphogenesis
pulmonary valve morphogenesis
atrioventricular valve formation
epithelial to mesenchymal transition involved in endocardial cushion formation
endocardial cushion to mesenchymal transition involved in heart valve formation
endocardial cushion morphogenesis
cardiac ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
anterior/posterior axis specification
negative regulation of gene expression
mesenchymal cell development
dorsal aorta morphogenesis
umbilical cord morphogenesis
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cardiac epithelial to mesenchymal transition
cardiac septum morphogenesis
ventricular septum morphogenesis
labyrinthine layer blood vessel development
artery development
arterial endothelial cell differentiation
Notch signaling involved in heart development
negative regulation of transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
regulation of vasculogenesis
