Invitrogen

HEY2 Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
HEY2 Polyclonal Antibody

产品信息

PA5-25807

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
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免疫组化（石蜡） (IHC (P))

1:50-1:100
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 65-91 amino acids from the N-terminal region of human HEY2
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.46 mg/mL

纯化类型

Protein A, Antigen affinity chromatography

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2543307

产品详细信息

This antibody is predicted to react with bovine, canine, Xenopus and zebrafish based on sequence homology.

靶标信息

Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: bHLHb32; cardiovascular basic helix-loop-helix factor 1; Cardiovascular helix-loop-helix factor 1; Class B basic helix-loop-helix protein 32; h hHRT2; hairy and enhancer of split related 2; Hairy and enhancer of split-related protein 2; Hairy-E(spl)-related with YRPW motif 2; Hairy-related transcription factor 2; hairy/enhancer-of-split related with YRPW motif 2; Hairy/enhancer-of-split related with YRPW motif protein 2; hCHF1; hes-related family bHLH transcription factor with YRPW motif 2; HES-related repressor protein 1; HES-related repressor protein 2; HESR-2; hHRT2; HRT-2; mHRT2; Protein gridlock homolog

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基因别名: BHLHB32; CHF1; GRIDLOCK; GRL; HERP; HERP1; HESR2; HEY2; HRT2

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UniProt ID: (Human) Q9UBP5, (Mouse) Q9QUS4

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Entrez Gene ID: (Human) 23493, (Mouse) 15214

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功能
transcription factor activity, RNA polymerase II core promoter sequence-specific transcription factor activity, protein binding RNA polymerase II activating transcription factor binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding microsatellite binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding protein heterodimerization activity DNA binding protein dimerization activity basic helix-loop-helix transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter vasculogenesis muscular septum morphogenesis outflow tract morphogenesis pulmonary valve morphogenesis tricuspid valve morphogenesis tricuspid valve formation endocardial cushion to mesenchymal transition involved in heart valve formation cardiac ventricle morphogenesis cardiac left ventricle morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis transcription, DNA-templated Notch signaling pathway anterior/posterior axis specification positive regulation of heart rate negative regulation of transcription by transcription factor localization negative regulation of gene expression negative regulation of cardiac muscle cell apoptotic process mesenchymal cell development cardiac muscle hypertrophy in response to stress ascending aorta morphogenesis dorsal aorta morphogenesis umbilical cord morphogenesis cell fate commitment regulation of auditory receptor cell differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter smooth muscle cell differentiation ventricular cardiac muscle cell development positive regulation of cardiac muscle cell proliferation cardiac epithelial to mesenchymal transition heart trabecula formation cardiac septum morphogenesis ventricular septum morphogenesis atrial septum morphogenesis negative regulation of transcription initiation from RNA polymerase II promoter labyrinthine layer blood vessel development arterial endothelial cell differentiation cardiac vascular smooth muscle cell development coronary vasculature morphogenesis pulmonary artery morphogenesis Notch signaling involved in heart development protein-DNA complex assembly cochlea development vascular smooth muscle cell development negative regulation of transcription regulatory region DNA binding negative regulation of cardiac vascular smooth muscle cell differentiation negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation regulation of vasculogenesis blood vessel development atrioventricular valve development cardiac muscle hypertrophy regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development pattern specification process regulation of gene expression artery development
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