Invitrogen

HIF-1 beta Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
HIF-1 beta Polyclonal Antibody

产品信息

PA5-85521

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:3,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:1,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the C-terminus region of human HIF1 beta. The exact sequence is proprietary.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2792661

产品详细信息

Keep as concentrated solution.

Predicted reactivity: Mouse (84%), Rat (82%), Pig (91%), Rabbit (86%), Sheep (91%), Bovine (92%), Guinea pig (92%).

Positive Control: 293T, A431, HeLa, HepG2 (untreated), HepG2 ( 1% O2 treatment for 24hr).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease. HIF-1 is a nuclear protein involved in mammalian oxygen homeostasis. This occurs as a posttranslational modification by prolyl hydroxylation. HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Both subunits are constantly translated. However, under normoxic conditions, human HIF-1 alpha is hydroxylated at Pro402 or Pro564 by a set of HIF prolyl hydroxylases, is polyubiquinated, and eventually degraded in proteosomes. Under hypoxic conditions, the lack of hydroxylation prevents HIF degradation and increases transcriptional activity. Therefore, the concentration of HIF-1 alpha increases in the cell. In contrast, HIF-1 beta remains stable under either condition. HIF-1 beta is a series of aryl hydrocarbon receptor nuclear translocator (ARNT) gene products. Diseases associated with HIF-1 beta dysfunction include hypoxia and renal cell carcinoma.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: ARNT protein; Aryl hydrocarbon receptor nuclear translocator; bHLHe2; Class E basic helix-loop-helix protein 2; Dioxin receptor, nuclear translocator; hif 1; HIF-1-beta; HIF1 beta; HIF1-beta; hypoxia-inducible factor 1, beta subunit; Hypoxia-inducible factor 1-beta

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基因别名: ARNT; BHLHE2; D3Ertd557e; Drnt; ESTM42; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; mKIAA4051; TANGO; W08714

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UniProt ID: (Human) Q5QP39, (Mouse) P53762

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Entrez Gene ID: (Human) 405, (Mouse) 11863

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功能
transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity aryl hydrocarbon receptor activity protein binding transcription factor binding aryl hydrocarbon receptor binding enhancer binding sequence-specific DNA binding protein heterodimerization activity transcription factor activity, transcription factor binding DNA binding signal transducer activity protein dimerization activity basic helix-loop-helix transcription factor
参与通路
response to hypoxia embryonic placenta development positive regulation of endothelial cell proliferation transcription, DNA-templated positive regulation of vascular endothelial growth factor production cell differentiation intracellular receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of protein sumoylation mRNA transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter in response to oxidative stress positive regulation of erythrocyte differentiation positive regulation of glycolytic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of hormone biosynthetic process regulation of transcription from RNA polymerase II promoter in response to hypoxia regulation of transcription, DNA-templated signal transduction response to toxic substance regulation of nucleic acid-templated transcription
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