Invitrogen

HIRA Polyclonal Antibody

Name: HIRA Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-62234

高级验证

查看其他6个HIRA抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)
高级验证 (1)

HIRA Antibody in Immunohistochemistry (IHC)

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HIRA Antibody (PA5-62234) in IHC

Immunohistochemical staining of HIRA in human thyroid gland and liver tissues using HIRA Polyclonal Antibody (Product # PA5-62234). Corresponding HIRA RNA-seq data are presented for the same tissues.

Product Image Gallery

HIRA Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of HIRA demonstrates antibody specificity. Immunohistochemical analysis of HIRA using anti-HIRA Polyclonal Antibody (Product # PA5-62234), shows significant staining of HIRA in human thyroid gland and shows minimal or weak staining in human liver tissues. The relative expression levels of HIRA within each tissue is shown using RNA-Seq. {RE}

Immunogen image

Immunogen Image HIRA Polyclonal Antibody

产品信息

PA5-62234

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human HIRA. Recombinant protein control fragment (Product #RP-103085).

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.05 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2642445

产品详细信息

Immunogen sequence: LKLPIPSPQR AFTLQVSSDP SMYIEVENEV TVVGGVKLSR LKCNREGKEW ETVLTSRILT AAGSCDVVCV ACEKRMLSVF STCGRRLLSP ILLPSPISTL HC

Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.

靶标信息

HIRA is a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this protein in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochromatin. It plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate protein in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.

仅用于科研。不用于诊断过程。未经明确授权不得转售。