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Invitrogen
HIV1 Rev Group M Monoclonal Antibody (10)
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产品信息
MA1-71514
产品规格
种属反应
Virus
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
10
抗原
Recombinant Rev protein of HIV-1 BRV purified from E. coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts with HIV-1 Rev subtype B. It has been mapped to amino acids 34-40 (TRGARRN - subtype B a.a. consensus).
This clone may also be referred to as 10 (03-002).
靶标信息
The HIV-1 Rev (regulator of expression of virion) protein is essential for the replication of HIV-1, especially in group M, which is the predominant and most widespread group of HIV-1 responsible for the global HIV epidemic. The Rev protein is encoded by the rev gene and plays a critical role in the nuclear export of unspliced and singly spliced viral mRNAs, which is crucial for the expression of structural proteins and the production of new virions. Structurally, Rev consists of an arginine-rich motif that allows it to bind to the Rev Response Element (RRE) within the viral RNA. This interaction facilitates the recruitment of the nuclear export receptor CRM1, which, along with other cofactors, translocates the RNA out of the nucleus. Functional disruption of Rev or its interaction with RRE significantly impedes HIV-1 replication, making these interactions potential targets for antiretroviral therapies.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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