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Invitrogen
HIV1 Tat Monoclonal Antibody (7)
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产品信息
MA1-71509
应用
建议稀释比
已发表文章
产品规格
种属反应
Virus
已发表种属
Virus
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
7
抗原
Recombinant Tat protein of HIV-1 BH10 purified from E. coli
偶联物
形式
Liquid
浓度
1.0 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4
内含物
0.1% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody reacts with HIV-1 Tat BH10, IIIB strains. This antibody reacts with the rTat consensus sequences of HIV-1 subtypes A (PNLEPWH), B (PRLEPWK) and C (PNLEPWN). It has been mapped to amino acids 6-12 (PRLEPWK - B subtype a.a. consensus).
MA1-71509 can be used for chromatin immunoprecipitation (ChIP) analysis of HIV1 Tat.
This clone may also be referred to as 7 (02-002).
靶标信息
HIV-1 Tat ("Trans-Activator of Transcription") consists of 86 to 101 amino acids depending on the subtype. Tat is critical to HIV reproduction by way of compensating for a defect in its genome: the HIV RNA initially has a hairpin-structured portion which prevents full transcription from occurring. However, a small number of RNA transcripts will be made, which allow the Tat protein to be produced. Tat then binds to and phosphorylates cellular factors, eliminating the effect of the hairpin RNA structure and allowing transcription of the HIV RNA. This increases the rate of transcription, providing a positive feedback cycle. The protein is released by infected cells in culture, and is found in the blood of HIV-1 infected patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
