Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
HIV1 Vif VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1421)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
MA5-54351
产品规格
种属反应
Virus
宿主/亚型
Alpaca
/ VHH
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
SAA1421
抗原
Recombinant HIV-1 Vif/SOR protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Metal-chelate chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
产品详细信息
Compatible with Direct ELISA
靶标信息
The HIV-1 viral infectivity factor (Vif) is a crucial protein for the efficient replication of the virus, particularly in non-permissive cells such as lymphocytes and macrophages. Vif is a basic phosphoprotein with a molecular weight of approximately 23,000 Daltons. Its primary function is to counteract the host cellular antiviral protein APOBEC3G, which induces hypermutations in the viral DNA, thereby inhibiting viral replication. Vif achieves this by targeting APOBEC3G for ubiquitination and subsequent degradation, thus preventing it from incorporating into new virions. Structurally, Vif interacts with the cellular ubiquitin-proteasome machinery to facilitate the degradation of APOBEC3G. This interaction is essential for Vif's role in viral replication and immune evasion. Additionally, Vif has been shown to suppress the production of type I interferon by targeting the immune signaling molecule STING, further aiding in immune evasion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
