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Invitrogen
HLA-AB Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-86049
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein within Human HLA Class 1 ABC aa 125-325.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% Glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
HLA-AB refers to the human leukocyte antigen (HLA) class I molecule, specifically the HLA-A and HLA-B loci. HLA-AB plays a critical role in the immune system by presenting peptides derived from intracellular proteins to CD8+ T cells. Its widespread presence on nucleated cells allows for immune surveillance and targeted elimination of infected or abnormal cells. HLA-AB consists of a heavy chain (encoded by the HLA-A or HLA-B gene) and a beta-2 microglobulin chain. The heavy chain contains three extracellular domains: alpha-1, alpha-2, and alpha-3. These domains form a peptide-binding groove that accommodates antigenic peptides. The beta-2 microglobulin chain is non-covalently associated with the heavy chain and stabilizes the structure of the HLA-AB complex. The structure of HLA-AB enables it to bind and present a diverse range of antigenic peptides, facilitating the recognition and response to intracellular pathogens.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HLA class I histocompatibility antigen, A alpha chain; HLA class I histocompatibility antigen, B alpha chain; HLA-A; HLA-B; Human leukocyte antigen A; Human leukocyte antigen B
基因别名: HLA-A; HLA-B; HLAA; HLAB
Entrez Gene ID: (Human) 3105, (Human) 3106
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
