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Invitrogen
HLA-B7 Monoclonal Antibody (BB7.1), APC, eBioscience™
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HLA-B7 Antibody (17-5917-42) in Flow
Normal human peripheral blood cells from a HLA-B7 positive donor were stained with Mouse IgG1 kappa Isotype Control, APC (Product # 17-4714-82) (blue histogram) or HLA-B7 Monoclonal Antibody, APC (purple histogram). Cells in the lymphocyte gate were used for analysis.
产品信息
17-5917-42
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
BB7.1
抗原
Papain solubilized HLA-B7
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with BSA
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: This BB7.1 monoclonal antibody recognizes the human major histocompatibility complex MHC class I molecule HLA-B7, which is a member of the HLA-B family. MHC class I exists as a heterodimer composed of a specific alpha chain associated with a beta 2-microglobulin. MHC class I molecules are expressed on all nucleated cells.
Applications Reported: This BB7.1 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This BB7.1 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser
靶标信息
HLA-B7 is one of the polymorphic proteins of human MHC Class I found on all nucleated cells. This surface protein is a heterodimer consisting of the specific transmembrane HLA-B chain paired with Beta-2 microglobulin. Classical MHC Class I molecules play a central role in adaptive immunity by presenting to T cells antigenic peptides derived either from the cell itself (classical presentation) or extracellular antigens (cross-presentation). The ligands of MHC class I include T cell receptor (TCR) and a costimulatory molecule CD8. Hundreds of HLA-B alleles have been described. Typing for these polymorphisms is routinely done for transplantation.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: allele B-3515; B*3509; CDABP0067; cell surface glycoprotein; integral membrane protein; DAQB-90C11.16; FLJ26655; glycosylation aa 86, alpha domain 1 aa 1-24, alpha domain 2 aa 25-114, alpha domain 3 aa 207-298; glycosylation aa 86, alpha domain 1 aa 25-114, alpha domain 2 aa 115-206, alpha domain 3 aa 207-298; heavy chain; hla antigen; HLA B-1519; hla b7; HLA class I antigen HLA-B; HLA class I histocompatibility antigen, B alpha chain; HLA protein allele B37; HLA protein allele B51; HLA protein allele B57; HLA protein allele B7; HLA-A; HLA-B; HLA-B 1502; HLA-B*4002; HLA-B-07ZEL allele; HLA-B-1501; HLA-B-1516; HLA-B-1520 allele; HLA-B-15AOH allele; HLA-B-15ZEL allele; HLA-B-27KSH allele; HLA-B-67LAV allele; This submission reports an HLA-B-6701 variant (HLA-B-67LAV) that differs from the published B-6701 sequence, GenBank Accession Number L17005; HLA-B18; HLA-B27 peptide; HLA-B39; HLA-B41 variant; HLA-B61; HLA-Bw-39-DBU allele; Human leukocyte antigen B; leukocyte antigen class I-B; lymphocyte antigen; MHC 1; MHC class 1 antigen; MHC class I antigen HLA-B alpha chain; MHC class I antigen HLA-B heavy chain; MHC class I antigen SHCHA; MHC class I molecule; MHC class I-like alpha chain membrane-bound type; MHC HLA-B cell surface glycoprotein; MHC HLA-B transmembrane glycoprotein; MHC HLA-B44; MHC HLA-B7 heavy chain precursor; MHC HLA-Bw46; MHC1; similar to Homo sapiens MHC HLA-B39 mRNA with GenBank Accession Number L42024.1; subtype B*3508 differs at residue 156 (Leu->Arg) with subtype B*3501; unnamed protein product
基因别名: AS; B-4901; HLA-B; HLAB
UniProt ID: (Human) P01889
Entrez Gene ID: (Human) 3106
positive regulation of T cell mediated cytotoxicity
adaptive immune response
immune system process
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of endogenous peptide antigen via MHC class Ib
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
regulation of T cell anergy
defense response
immune response
detection of bacterium
antigen processing and presentation
regulation of interleukin-12 production
regulation of interleukin-6 production
protection from natural killer cell mediated cytotoxicity
innate immune response
regulation of dendritic cell differentiation
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