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NeoBiotechnologies
HLA-DP (MHC II) Monoclonal Antibody (SPM421)
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产品信息
3115-MSM1X-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b, kappa
分类
Monoclonal
类型
Antibody
克隆号
SPM421
抗原
Non-T, non-B human acute lymphoblastic leukemia REH6 cell line
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The human MHC class II is encoded by three different isotypes, HLA-DR, -DQ, and -DP, all are highly polymorphic. HLA-DP molecules have not been studied extensively. HLA-DP is a protein complex found on the surface of antigen-presenting cells, such as dendritic cells, macrophages, and B cells. Its main function is to present peptides derived from extracellular proteins to CD4+ T cells for immune recognition.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DP beta 1 domain protein; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA DP4 beta-chain; HLA-DP histocompatibility type, beta-1 subunit; light chain; MHC class II antigen DPB1; MHC class II HLA-DP-beta-1; MHC HLA DPB1; MHC HLA-DPw4b-beta chain precursor; MHC HLA-SB-beta chain I; SB-beta chain; unnamed protein product
基因别名: DPB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1
UniProt ID: (Human) P79608
Entrez Gene ID: (Human) 3115
adaptive immune response
immune system process
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
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