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Invitrogen
HLA-DPB1 Recombinant Rabbit Monoclonal Antibody (1X8F7)
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HLA-DPB1 Antibody (MA5-58200) in IHC (P)
Immunohistochemistry analysis of HLA-DPB1 with paraffin-embedded Mouse spleen tissue. The tissue was incubated with HLA-DPB1 Recombinant Monoclonal Antibody (Product # MA5-58200) using a 1:200 dilution (40x lens). Followed by Cy3-conjugated Goat anti-Rabbit IgG (H+L) Secondary Antibody (Red) using a 1:500 dilution. DAPI was used for nuclear staining (Blue). High pressure antigen retrieval performed with 0.0... View More
产品信息
MA5-58200
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1X8F7
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HLA-DPB1 (NP_002112.3).
偶联物
形式
Liquid
浓度
0.072 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
Immunogen sequence: MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA
靶标信息
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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