Search
Invitrogen
HLA-DR/DP/DQ Chimeric Recombinant Rabbit Monoclonal Antibody (F3.3)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 3
HLA-DR/DP/DQ Chimeric Antibody (MA5-47832) in WB
Western Blot analysis of HLA-DR/DP/DQ was performed using HLA-DR/DP/DQ Chimeric Monoclonal Antibody (Product # MA5-47832). Human spleen (A), human tonsil (B) and Daudi cell lysate (C) samples (35 µg protein in RIPA buffer) were resolved on a 10% SDS PAGE gel and blots probed with HLA-DR/DP/DQ Chimeric Monoclonal Antibody at 0.01 µg/mL before detection using an anti-rabbit secondary antibody. A primary incub... View More
产品信息
MA5-47832
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
F3.3
抗原
Proprietary sequence.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
200 µg
纯化类型
Protein A
保存液
PBS
内含物
0.02% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Specificity: Recognising anti-class II HLA molecules.
靶标信息
MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DP beta 1 domain protein; DR beta-5; DR2-beta-2; DR7 beta-chain glycoprotein; DRB1; DRB52; DRw53 beta-chain glycoprotein; Dw2; ERLA-005; FLJ75017; FLJ76359; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DP4 beta-chain; HLA DRB3; HLA-D; HLA-DP histocompatibility type, beta-1 subunit; HLA-DQ; HLA-DQ-beta-1 cell surface glycoprotein; HLA-DQB1; HLA-DR; HLA-DR alpha-chain; hla-dr antigen alpha chain; hla-dr antigen beta chain; hla-dr antigen heavy chain; HLA-DR-alpha chain precursor; HLA-DR-beta chain; HLA-DR11-14N allele; HLA-DRA; HLA-DRB1; human leucocyte antigen; human leucocyte antigen DRB1; human leucocyte antigen DRB3; Human leukocyte antigen DRB1; leukocyte antigen; light chain; lymphocyte antigen DRB1; major histocompatibility complex, class II, DRB3; MHC Class 2; MHC class II; MHC class II antigen; MHC class II antigen DPB1; MHC class II antigen DQB1; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II DQ-beta protein precursor; MHC class II DQ3.1ER protein; MHC class II DR beta chain; MHC class II HLA-DP-beta-1; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR4 protein; MHC class II HLA-DR4/w53 protein; MHC class II protein; MHC DQ beta protein precursor; MHC DQ-beta chain; MHC DQw1-beta surface glycoprotein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-1 chain; MHC DR7-beta-2 chain; MHC HLA DPB1; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-D; MHC HLA-DC-beta chain precursor; MHC HLA-DPw4b-beta chain precursor; MHC HLA-DQ-beta cell surface glycoprotein; MHC HLA-DQ-beta chain precursor old gene name 'HLA-DQB'; MHC HLA-DQ-beta precursor; MHC HLA-DQB1-beta protein; MHC HLA-DR-beta chain; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta surface glycoprotein; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-1 precursor; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)a glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)a glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DR2(non-Dw2/non-Dw12)a glycoprotein beta-chain; MHC HLA-DRQ-beta chain; MHC HLA-DRw10-beta-2 protein precursor; MHC HLA-SB-beta chain I; MHC II HLA; SB-beta chain; unnamed protein product; XXbac-BPG161M6.1
基因别名: CELIAC1; DPB1; DR4; DRB1; DRB3; DRB4; DRB5; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB3*; HLA-DRB4; HLA-DRB4*; HLA-DRB5; HLA-DRB5*; IDDM1; SS1
UniProt ID: (Human) P79608, (Human) P01920, (Human) P01903, (Human) P01911, (Human) P79483, (Human) P13762, (Human) Q30154
Entrez Gene ID: (Human) 3115, (Human) 3119, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127
adaptive immune response
immune system process
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of interferon-gamma production
positive regulation of T cell proliferation
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of T cell mediated cytotoxicity
myeloid dendritic cell antigen processing and presentation
antigen processing and presentation of endogenous peptide antigen via MHC class II
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of memory T cell differentiation
regulation of T-helper cell differentiation
cognition
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of T cell mediated immune response to tumor cell
signal transduction
humoral immune response
positive regulation of protein phosphorylation
inflammatory response to antigenic stimulus
negative regulation of inflammatory response to antigenic stimulus
cytoskeleton organization
epidermis development
detection of bacterium
macrophage differentiation
regulation of interleukin-10 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
positive regulation of kinase activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of MAPK cascade
positive regulation of monocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of viral entry into host cell
protein tetramerization
positive regulation of ERK1 and ERK2 cascade
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
