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Invitrogen
HLA-DR beta Polyclonal Antibody
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HLA-DR beta Antibody (PA5-21410) in ICC/IF
Immunofluorescence analysis of HLA-DR beta was performed using 70% confluent log phase Raji cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with HLA-DR beta Polyclonal Antibody (Product # PA5-21410) at 1:200 in 0.1% BSA, incubated at 4 degree celsius o... View More
产品信息
PA5-21410
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human HLA-DR beta. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Raji.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DAMC-146E17.2; DR beta-5; DR2-beta-2; DR7 beta-chain glycoprotein; DRB1; DRB52; DRw53 beta-chain glycoprotein; Dw2; ERLA-005; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DRB3; HLA-DR-beta chain; HLA-DR11-14N allele; HLA-DRB1; human leucocyte antigen; human leucocyte antigen DRB1; human leucocyte antigen DRB3; Human leukocyte antigen DRB1; leukocyte antigen; lymphocyte antigen DRB1; major histocompatibility complex, class II, DRB3; MHC class II antigen; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II DR beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR4 protein; MHC class II HLA-DR4/w53 protein; MHC class II protein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-1 chain; MHC DR7-beta-2 chain; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-DR-beta chain; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta surface glycoprotein; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-1 precursor; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)a glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)a glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DR2(non-Dw2/non-Dw12)a glycoprotein beta-chain; MHC HLA-DRw10-beta-2 protein precursor; unnamed protein product
基因别名: DR4; DRB1; DRB3; DRB4; DRB5; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB3*; HLA-DRB4; HLA-DRB4*; HLA-DRB5; HLA-DRB5*; SS1
UniProt ID: (Human) P01911, (Human) P79483, (Human) P13762, (Human) Q30154
Entrez Gene ID: (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127
adaptive immune response
immune system process
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
immune response
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of immune response
positive regulation of T cell activation
myeloid dendritic cell antigen processing and presentation
positive regulation of T cell mediated immune response to tumor cell
signal transduction
T cell receptor signaling pathway
positive regulation of CD4-positive, alpha-beta T cell activation
positive regulation of T cell mediated cytotoxicity
positive regulation of protein phosphorylation
inflammatory response to antigenic stimulus
antigen processing and presentation of endogenous peptide antigen via MHC class II
negative regulation of inflammatory response to antigenic stimulus
humoral immune response
cytoskeleton organization
epidermis development
detection of bacterium
macrophage differentiation
regulation of interleukin-10 production
regulation of interleukin-4 production
negative regulation of interferon-gamma production
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
positive regulation of kinase activity
positive regulation of insulin secretion involved in cellular response to glucose stimulus
T-helper 1 type immune response
negative regulation of T cell proliferation
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of memory T cell differentiation
positive regulation of MAPK cascade
regulation of T-helper cell differentiation
positive regulation of monocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of viral entry into host cell
protein tetramerization
positive regulation of ERK1 and ERK2 cascade
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