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NeoBiotechnologies
HLA-DRB (MHC II) Monoclonal Antibody (L243)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
3123-MSM3-P0
产品规格
种属反应
Dog,
Chimpanzee,
Human,
Non-human primate,
Rodent
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
L243
抗原
Activated human peripheral blood mononuclear cells
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
20 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
HLA-DR beta refers to the beta chain of the HLA-DR protein complex, which is a member of the human leukocyte antigen (HLA) class II molecule. The HLA-DR beta chain is encoded by the HLA-DRB gene. HLA-DR beta is primarily on the surface of antigen-presenting cells, including dendritic cells, macrophages, and B cells. These cells play a crucial role in the immune system by capturing, processing, and presenting antigens to T cells for immune recognition. HLA-DR beta is a critical component of the immune system, facilitating the recognition and response to extracellular antigens. Its function in presenting antigenic peptides to CD4+ T cells plays a vital role in the activation of adaptive immune responses. HLA-DR beta consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail. The extracellular domain contains the peptide-binding groove, which interacts with antigenic peptides. The transmembrane domain anchors the HLA-DR beta chain to the cell membrane, while the cytoplasmic tail is involved in intracellular signaling events.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DAMC-146E17.2; DLA class II histocompatibility antigen, DR-1 beta chain; DLA DRBB1 beta chain; DLA-DR beta; DR beta-5; DR2-beta-2; Dw2; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-DRB1; Human leukocyte antigen DRB1; MHC class II antigen beta chain; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II DLA-DR-beta-1; MHC class II DLA-DRB; MHC class II DR beta 1; MHC DLA-DR-beta-1 precursor
基因别名: DLA-DRB1; DLA-DRBB1; DRB; DRB1; DRBB1; HLA-DRB1; HLA-DRB3; HLA-DRB4; HLA-DRB5; LA-DRB
UniProt ID: (Dog) P18470
Entrez Gene ID: (Dog) 474860
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
