Search
Invitrogen
HLA-DRB3 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
产品信息
PA5-98351
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human HLA class II histocompatibility antigen, DR beta 3 chain protein (111-227AA)
偶联物
形式
Liquid
浓度
3.5 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain ( beta-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: DR7 beta-chain glycoprotein; HLA class II histocompatibility antigen, DR beta 3 chain; HLA DR3B; HLA DRB3; human leucocyte antigen DRB3; leukocyte antigen; major histocompatibility complex, class II, DRB3; MGC117330; MHC class II antigen DR beta 3 chain; MHC class II antigen DRB3; MHC class II DR beta chain; MHC class II HLA-DR beta 3 chain; MHC class II protein; unnamed protein product
基因别名: DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3; HLA-DRB3*
UniProt ID: (Human) P79483
Entrez Gene ID: (Human) 3125
adaptive immune response
immune system process
myeloid dendritic cell antigen processing and presentation
peptide antigen assembly with MHC class II protein complex
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
positive regulation of T cell mediated immune response to tumor cell
immune response
signal transduction
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
positive regulation of immune response
T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of CD4-positive, alpha-beta T cell activation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
