NeoBiotechnologies

HLA-E (Major histocompatibility complex, class I, E) Monoclonal Antibody (HLAE/9467)

Name: HLA-E (Major histocompatibility complex, class I, E) Monoclonal Antibody (HLAE\/9467)
Brand: NeoBiotechnologies
SKU: 3133-MSM1-P1ABX

查看其他26个HLA-E抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (3)

HLA-E (Major histocompatibility complex, class I, E) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HLA-E (Major histocompatibility complex, class I, E) Antibody (3133-MSM1-P1ABX) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with HLA-E Mouse Monoclonal Antibody (HLAE/9467). Inset: PBS instead of primary antibody; secondary only negative control.

HLA-E (Major histocompatibility complex, class I, E) Antibody in Western Blot (WB)

HLA-E (Major histocompatibility complex, class I, E) Antibody in SDS-PAGE (SDS-PAGE)

Product Image Gallery

Immunogen image

Immunogen Image HLA-E (Major histocompatibility complex, class I, E) Monoclonal Antibody (HLAE/9467)

产品信息

3133-MSM1-P1ABX

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2-4 µg/mL

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

HLAE/9467

抗原

Recombinant fragment (around aa 1-200) of human HLAE protein (exact sequence is proprietary).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

-20°C or -80°C if preferred

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product cellular localization: Cell membrane, Secreted.

Positive control: Human tonsil, lymph node or spleen. HEK293 cells.

Tissue specificity: Expressed in secretory endometrial cells during pregnancy (at protein level). The expression in nonlymphoid tissues is restricted to endothelial cells from all types of vessels, including arteries, veins, capillaries, and lymphatics (at protein level). In lymphoid organs, it is mainly expressed in endothelial venules, B and T cells, monocytes, macrophages, NK cells and megakaryocytes (at protein level).

靶标信息

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: DAMA-277I14.1; DAQB-90C11.16; DKFZp686P19218; FLJ26655; HLA class I histocompatibility antigen, alpha chain E; HLA class I histocompatibility antigen, E alpha chain; lymphocyte antigen; MHC 1; MHC class I antigen E; MHC HLA-E alpha-1; MHC HLA-E alpha-2.1; MHC1

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基因别名: EA1.2; EA2.1; HLA-6.2; HLA-E; HLAE; MHC; QA1

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UniProt ID: (Human) P13747

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Entrez Gene ID: (Human) 3133

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功能

receptor binding beta-2-microglobulin binding MHC class I protein binding peptide antigen binding natural killer cell lectin-like receptor binding major histocompatibility complex protein

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