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Invitrogen
HLA-F Recombinant Rabbit Monoclonal Antibody (24GB3830)
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HLA-F Antibody (MA5-57037) in ICC/IF
Immunocytochemical staining of HLA-F in Hela cells using HLA-F Recombinant Monoclonal Antibody (Product # MA5-57037) at a 1:1,1000 dilution. Nuclei were stained blue with DAPI; HLA-F was stained magenta with Alexa Fluor® 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar: 20 μm.
产品信息
MA5-57037
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
24GB3830
抗原
A synthesized peptide derived from human HLA F (aa 25-76)
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
HLA-F belongs to the HLA class I heavy chain paralogues. It is a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDA12; HLA class I histocompatibility antigen, alpha chain F; HLA class I molecule; HLA F antigen; Leukocyte antigen F; MHC class I antigen F; MHC class Ib antigen
基因别名: CDA12; HLA-5.4; HLA-CDA12; HLA-F; HLAF
UniProt ID: (Human) P30511
Entrez Gene ID: (Human) 3134
antigen processing and presentation of peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
regulation of immune response
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
