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Invitrogen
HMGA1 Recombinant Rabbit Monoclonal Antibody (5J0E6)
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HMGA1 Antibody (MA5-35485) in ICC/IF
Confocal imaging (Immunocytochemistry) of HMGA1 in U-2 OS cells. Samples were incubated with HMGA1 Monoclonal antibody (Product # MA5-35485) using a dilution of 1:100 (Red). The cells were counterstained with alpha Tubulin Mouse mAb (dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 100x.
产品信息
MA5-35485
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
5J0E6
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-107 of human HMGA1 (P17096)
偶联物
形式
Liquid
浓度
1.6 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR PKGSKNKGAA KTRKTTTTPG RKPRGRPKKL EKEEEEGISQ ESSEEEQ
靶标信息
HMGA1 encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:5010; High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein HMG-I/HMG-Y; high mobility group protein I; High mobility group protein R; high-mobility group (nonhistone chromosomal) protein isoforms I and Y; HMG-I(Y); MGC12816; MGC4242; MGC4854; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y; OTTHUMP00000016222; OTTHUMP00000016223; OTTHUMP00000016224; OTTHUMP00000039618
基因别名: AL023995; HMG-R; HMGA1; HMGA1A; Hmga1b; Hmgi; HMGIY; Hmgy
UniProt ID: (Human) P17096, (Mouse) P17095, (Rat) Q8K585
Entrez Gene ID: (Human) 3159, (Mouse) 15361, (Rat) 117062
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
DNA binding
AT DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
transcription factor binding
enzyme binding
ligand-dependent nuclear receptor transcription coactivator activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
retinoid X receptor binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA-(apurinic or apyrimidinic site) lyase activity
5'-deoxyribose-5-phosphate lyase activity
endodeoxyribonuclease
DNA unwinding involved in DNA replication
nucleosome disassembly
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein complex assembly
negative regulation of cell proliferation
response to virus
negative regulation of chromatin silencing
senescence-associated heterochromatin focus assembly
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
nuclear transport
establishment of integrated proviral latency
oncogene-induced cell senescence
positive regulation of cellular senescence
DNA metabolic process
base-excision repair
spermatogenesis
nucleic acid phosphodiester bond hydrolysis
regulation of nucleic acid-templated transcription
DNA catabolic process, endonucleolytic
transcription, DNA-templated
