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Invitrogen
HMGA1B Polyclonal Antibody
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产品信息
PA5-149106
产品规格
种属反应
Human,
Mouse
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived recombinant human HMGA1B, Met1-Glu96
偶联物
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.2 mg/mL in sterile PBS.
靶标信息
HMGA1B (High Mobility Group AT-Hook 1B) is a gene that encodes a member of the high mobility group A (HMGA) family of proteins, which are known for their role in regulating chromatin structure and gene expression. HMGA1B proteins are characterized by their AT-hook motifs, which allow them to bind to the minor groove of AT-rich regions in DNA. This binding can influence the architecture of chromatin, thereby modulating the access of transcription factors and other regulatory proteins to DNA. HMGA1B is implicated in various cellular processes, including differentiation, proliferation, and apoptosis. Overexpression or dysregulation of HMGA1B is often associated with tumorigenesis and has been observed in numerous cancers, such as breast, prostate, and pancreatic cancers. This protein can promote oncogenic transformation by altering the expression of genes involved in cell growth and survival. Additionally, HMGA1B has been linked to metabolic disorders and developmental abnormalities. Understanding the function and regulation of HMGA1B is crucial for developing targeted therapies aimed at modulating its activity in cancer and other diseases. Research into HMGA1B provides valuable insights into its role in chromatin dynamics and gene regulation, highlighting its potential as a therapeutic target and biomarker for disease diagnosis and prognosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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