Invitrogen

HMGCR Monoclonal Antibody (CL0260)

Name: HMGCR Monoclonal Antibody (CL0260)
Brand: Invitrogen
SKU: MA5-31336

高级验证

查看其他15个HMGCR抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (6)
高级验证 (1)

HMGCR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HMGCR Antibody (MA5-31336) in IHC (P)

Immunohistochemistry analysis of HMGCR in human liver and skeletal muscle tissues. Samples were incubated with HMGCR monoclonal antibody (Product # MA5-31336). Corresponding HMGCR RNA-seq data are presented for the same tissues.

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HMGCR Antibody — Antibody specificity was demonstrated by siRNA mediated knockdown of target protein. MCF-7 cells were transfected with, control siRNA, HMGCR siRNA probe #1, and HMGCR siRNA probe #2 and a decrease in signal intensity was observed in Western Blot application using anti-HMGCR Monoclonal Antibody (CL0260) (Product # MA5-31336) used at a dilution of 1 µg/mL. Anti-HMGCR was used as a loading control. {KD}

产品信息

MA5-31336

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

免疫组化（石蜡） (IHC (P))

1:20-1:50

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

CL0260

抗原

Recombinant protein corresponding to Human HMGCR

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2786973

产品详细信息

Immunogen sequence: GAKFLSDAEI IQLVNAKHIP AYKLETLMET HERGVSIRRQ LLSKKLSEPS SLQYLPYRDY NYSLVMGACC ENVIGYMPIP VGVAGPLCLD EKEFQVPMAT TEGCLVASTN RGCRAIGLGG GASSRVLADG MTRGPVVRLP RACDSAEVKA WLETSEGFAV IKEAFDSTSR FARLQKLHTS IAGRNLYIRF QSRSGDAMGM NMISKGTEKA LSKLHEYFPE MQILAVSGNY CTDKKPAAIN WIEGRGKSVV CEAVIPAKVV REVLKTTT

Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 92%.

靶标信息

3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269

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基因别名: HMGCR; LDLCQ3

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UniProt ID: (Human) P04035

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Entrez Gene ID: (Human) 3156

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功能