Invitrogen

HNF4A/HNF4G Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
HNF4A/HNF4G Polyclonal Antibody

产品信息

PA5-100879

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human HNF4A(Accession P41235), corresponding to amino acid residues A287-L337.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2815829

产品详细信息

Antibody detects endogenous levels of total HNF4 alpha /gamma.

靶标信息

The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: alpha transcription factor 4; hepatic nuclear factor 4 alpha; hepatic nuclear factor 4, alpha; hepatocyte nuclear factor 4, alpha; hepatocyte nuclear factor 4, gamma; Hepatocyte nuclear factor 4-alpha; Hepatocyte nuclear factor 4-gamma; HNF-4-alpha; HNF-4-gamma; HNF4 alpha; HNF4alpha10; HNF4alpha10/11/12; HNF4alpha11; HNF4alpha12; Nuclear receptor 2A1; Nuclear receptor subfamily 2 group A member 1; Nuclear receptor subfamily 2 group A member 2; TCF-14; Transcription factor 14; Transcription factor HNF-4

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基因别名: FRTS4; HNF-4; HNF4; HNF4A; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; HNF4G; MODY; MODY1; NR2A1; NR2A2; NR2A21; NR2A3; TCF; TCF14

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UniProt ID: (Human) P41235, (Human) Q14541, (Mouse) P49698, (Rat) P22449, (Mouse) Q9WUU6

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Entrez Gene ID: (Human) 3172, (Human) 3174, (Mouse) 15378, (Rat) 25735, (Mouse) 30942, (Rat) 365744

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功能
fatty-acyl-CoA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II activating transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding fatty acid binding protein binding zinc ion binding palmitoyl-CoA hydrolase activity protein homodimerization activity transcription regulatory region DNA binding sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding transcription factor binding metal ion binding repressing transcription factor binding C4 zinc finger nuclear receptor
参与通路
regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter ornithine metabolic process lipid metabolic process acyl-CoA metabolic process xenobiotic metabolic process establishment of tissue polarity sex differentiation blood coagulation negative regulation of cell proliferation response to glucose regulation of gastrulation regulation of lipid metabolic process signal transduction involved in regulation of gene expression cell differentiation negative regulation of cell growth intracellular receptor signaling pathway regulation of microvillus assembly negative regulation of protein import into nucleus, translocation response to drug negative regulation of tyrosine phosphorylation of Stat5 protein glucose homeostasis steroid hormone mediated signaling pathway negative regulation of sequence-specific DNA binding transcription factor activity cell-cell junction organization positive regulation of gluconeogenesis positive regulation of fatty acid biosynthetic process positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion response to cAMP lipid homeostasis phospholipid homeostasis SMAD protein signal transduction triglyceride homeostasis negative regulation of activation of JAK2 kinase activity positive regulation of cholesterol homeostasis transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter
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