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Invitrogen
HO-1 Recombinant Rabbit Monoclonal Antibody (HL1780)
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HO-1 Antibody (MA5-47178) in WB
Western blot analysis of HO-1 in wild-type (WT) and HMOX1 knockout (KO) HeLa cell extracts (30 µg) separated by 12% SDS-PAGE. Membrane was blotted with HO-1 Monoclonal antibody (Product # MA5-47178) using a dilution of 1:2,000 followed by HRP-conjugated anti-rabbit IgG secondary antibody. The signal was developed with Trident ECL plus-Enhanced.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-47178
产品规格
种属反应
Cat,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1780
抗原
Recombinant fragment of human Heme Oxygenase 1
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules, biliverdin and carbon monoxide. HO consists of two homologous isozymes, an inducible HO-1 and a constitutively expressed HO-2. HO-1 is induced by a wide variety of stimuli including conditions of oxidative stress, inflammatory agents, transforming growth factor beta and heat shock. The increase in expression of HO-1 is thought to be a cellular defense mechanism against oxidative stress since elevated HO could eventually generate more bilirubin, an anti-oxidant.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: heme orygenase 1; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; Heme oxygenase 1; hemoxygenase; HO-1; HSP32; P32 protein
基因别名: D8Wsu38e; Hemox; Heox; HEOXG; Hmox; HMOX1; HO; HO-1; HO1; Hsp32
UniProt ID: (Rat) P06762, (Mouse) P14901
Entrez Gene ID: (Rat) 24451, (Mouse) 15368
angiogenesis
response to hypoxia
wound healing involved in inflammatory response
phospholipid metabolic process
heme oxidation
response to oxidative stress
small GTPase mediated signal transduction
regulation of blood pressure
cell death
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of muscle cell apoptotic process
cellular response to nutrient
negative regulation of mast cell cytokine production
erythrocyte homeostasis
regulation of transcription from RNA polymerase II promoter in response to iron
cellular response to heat
response to nicotine
intracellular signal transduction
heme catabolic process
heme metabolic process
response to hydrogen peroxide
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of mast cell degranulation
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of neuron apoptotic process
regulation of transcription from RNA polymerase II promoter in response to oxidative stress
response to estrogen
positive regulation of angiogenesis
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
regulation of sequence-specific DNA binding transcription factor activity
protein homooligomerization
iron ion homeostasis
cellular response to arsenic-containing substance
cellular response to cadmium ion
cellular response to hypoxia
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
cellular iron ion homeostasis
apoptotic process
oxidation-reduction process
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