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Invitrogen
HOXA13 Recombinant Rabbit Monoclonal Antibody (K01_4K48)
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产品信息
MA567260
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4K48
抗原
A synthesized peptide derived from human HOXA13.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box 1J; homeo box A13; homeobox A13; Homeobox protein Hox-1.10; Homeobox protein Hox-1J; Homeobox protein Hox-A13; homeobox protein HOXA13; hypodactyly; transcription factor HOXA13
基因别名: Hd; Hox-1.10; HOX1; HOX1J; HOXA13; RGD1562483
UniProt ID: (Human) P31271, (Mouse) Q62424
Entrez Gene ID: (Human) 3209, (Rat) 500129, (Mouse) 15398
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
molecular_function
protein binding
transcription regulatory region DNA binding
regulation of transcription, DNA-templated
embryonic hindgut morphogenesis
vasculogenesis
endothelial cell morphogenesis
tissue homeostasis
ventricular septum development
transcription, DNA-templated
multicellular organism development
anatomical structure morphogenesis
organ morphogenesis
regulation of BMP signaling pathway
male genitalia development
embryonic forelimb morphogenesis
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
inner ear development
artery morphogenesis
branching involved in prostate gland morphogenesis
endothelial cell fate specification
positive regulation of mesenchymal cell apoptotic process
skeletal system development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
prostate gland development
response to testosterone
mesenchymal cell apoptotic process
mitotic nuclear division
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