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Abnova
HOXA5 Monoclonal Antibody (3B9)
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产品信息
H00003202-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3B9
抗原
HOXA5 (NP_061975.1, 171 a.a. approximately 270 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Tissue lysate).
Immunogen sequence: PAQPQIYPWM RKLHISHDNI GGPEGKRART AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW KKDNKLKSMS MAAAGGAFRP
靶标信息
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA5 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: homeo box 1C; homeo box A5; Homeobox protein Hox-1C; Homeobox protein Hox-A5; homeobox protein HOXA5; Hox-1C
基因别名: HOX1; HOX1.3; HOX1C; HOXA5
UniProt ID: (Human) P20719
Entrez Gene ID: (Human) 3202
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
homeodomain transcription factor
respiratory system process
transcription from RNA polymerase II promoter
anterior/posterior pattern specification
positive regulation of receptor biosynthetic process
cell migration
negative regulation of angiogenesis
thyroid gland development
regulation of mammary gland epithelial cell proliferation
multicellular organism growth
positive regulation of apoptotic process
positive regulation of myeloid cell differentiation
negative regulation of erythrocyte differentiation
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
embryonic skeletal system morphogenesis
bronchiole development
epithelial tube branching involved in lung morphogenesis
lung goblet cell differentiation
lung-associated mesenchyme development
trachea cartilage morphogenesis
intestinal epithelial cell maturation
mesenchymal-epithelial cell signaling
mammary gland epithelial cell differentiation
mammary gland alveolus development
cell-cell signaling involved in mammary gland development
