Abnova

HPN Monoclonal Antibody (2D5)

Name: HPN Monoclonal Antibody (2D5)
Brand: Abnova
SKU: H00003249-M02

查看其他7个Hepsin抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

图: 1 / 2

HPN Antibody (H00003249-M02) in WB

HPN monoclonal antibody (M02), clone 2D5. Western Blot analysis of HPN expression in human liver.

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Immunogen image

Immunogen Image HPN Monoclonal Antibody (2D5)

产品信息

H00003249-M02

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

酶联免疫吸附实验 (ELISA)

3 ng/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

2D5

抗原

HPN (AAH25716.1, 40 a.a. approximately 417 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

See Label

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Sequence of this protein is as follows: VAVLLRSDQE PLYPVQVSSA DARLMVFDKT EGTWRLLCSS RSNARVAGLS CEEMGFLRAL THSELDVRTA GANGTSGFFC VDEGRLPHTQ RLLEVISVCD CPRGRFLAAI CQDCGRRKLP VDRIVGGRDT SLGRWPWQVS LRYDGAHLCG GSLLSGDWVL TAAHCFPERN RVLSRWRVFA GAVAQASPHG LQLGVQAVVY HGGYLPFRDP NSEENSNDIA LVHLSSPLPL TEYIQPVCLP AAGQALVDGK ICTVTGWGNT QYYGQQAGVL QEARVPIISN DVCNGADFYG NQIKPKMFCA GYPEGGIDAC QGDSGGPFAC EDSISRTPRW RLCGIVSWGT GCALAQKPGV YTKVSDFREW IFQAIKTHSE ASGMVTQL

靶标信息

Hepsin, encoded by the HPN gene, is a type II transmembrane serine protease prominently expressed in tissues such as the liver, kidney, and prostate. Hepsin plays a crucial role in proteolytic processes involved in extracellular matrix remodeling, cell growth, and development. It is known for activating precursor molecules, including hepatocyte growth factor (HGF), which is essential for liver development and regeneration. Furthermore, hepsin's involvement extends to influencing cell signaling pathways related to tissue homeostasis and repair. In the context of cancer, particularly prostate cancer, hepsin is implicated in tumor progression and metastasis by promoting extracellular matrix degradation, thereby facilitating tumor invasion and spread. Aberrant expression or activity of hepsin is associated with pathophysiological changes in the tumor microenvironment, making it a target for therapeutic interventions aimed at controlling cancer progression. Research continues to explore hepsin's biochemical functions and regulatory mechanisms, providing insights into its potential roles in both normal physiology and disease states.

仅用于科研。不用于诊断过程。未经明确授权不得转售。