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Invitrogen
HSC70 Polyclonal Antibody
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产品信息
PA5-96133
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 510-615 of human Hsc70/HSPA8 (NP_0065881)
偶联物
形式
Liquid
浓度
0.52 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LSKEDIERMV QEAEKYKAED EKQRDKVSSK NSLESYAFNM KATVEDEKLQ GKINDEDKQK ILDKCNEIIN WLDKNQTAEK EEFEHQQKEL EKVCNPIITK LYQSAG
Positive Samples: Cellular Location: Cell membrane, Cytoplasm, Melanosome, Nucleus, nucleolus
靶标信息
The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. HSC70 (also known as HSC71, HSC73, HSP73, p72, prp73) is expressed constitutively and is slightly heat-inducible. HSC70 binds to the exposed loop of clathrin light chains to promote uncoating and can also bind the cytoskeleton which may facilitate cytoskeletal rearrangements. HSC70 has been shown to stimulate lysosomal degradation of intracellular proteins and to retard both aggregation and folding of mitochondrial precursor proteins in vitro.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AAG2; constitutive heat shock protein 70; epididymis luminal protein 33; epididymis secretory sperm binding protein Li 72p; FAM10A1; Heat shock 70 kDa protein 8; heat shock 70kd protein 10; heat shock 70kD protein 8; heat shock 70kDa protein 8; Heat shock cognate 71 kDa protein; heat shock cognate hsc73; heat shock cognate protein 54; Heat shock cognate protein 70; heat shock protein 8; heat shock protein A8; heat shock protein cognate 70; Heat shock protein family A member 8; HIP; LAP; LAP-1; Lipopolysaccharide-associated protein 1; LPS-associated protein 1; MGC131511; MGC29929; N-myristoyltransferase inhibitor protein 71; Protein FAM10A1; SNC6
基因别名: 2410008N15Rik; HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; Hsc73; HSP71; HSP73; HSPA10; HSPA8; LAP-1; LAP1; NIP71
UniProt ID: (Human) P11142, (Rat) P63018, (Mouse) P63017
Entrez Gene ID: (Human) 3312, (Rat) 24468, (Mouse) 15481
G-protein coupled receptor binding
phosphatidylserine binding
protein binding
ATP binding
ATPase activity
enzyme binding
MHC class II protein complex binding
heat shock protein binding
ubiquitin protein ligase binding
ATPase activity, coupled
poly(A) RNA binding
unfolded protein binding
C3HC4-type RING finger domain binding
cadherin binding involved in cell-cell adhesion
receptor binding
ADP binding
nucleotide binding
transcription, DNA-templated
mRNA processing
protein folding
RNA splicing
protein refolding
negative regulation of transcription, DNA-templated
positive regulation of mRNA splicing, via spliceosome
chaperone mediated protein folding requiring cofactor
regulation of cell cycle
chaperone-mediated protein folding
clathrin coat disassembly
negative regulation of fibril organization
mRNA splicing, via spliceosome
protein targeting to lysosome
response to unfolded protein
neurotransmitter secretion
cellular response to starvation
viral process
regulation of protein stability
regulation of protein complex assembly
regulation of mRNA stability
ATP metabolic process
regulation of protein complex stability
chaperone-mediated autophagy
late endosomal microautophagy
protein targeting to lysosome involved in chaperone-mediated autophagy
chaperone-mediated protein transport involved in chaperone-mediated autophagy
cell-cell adhesion
regulation of cellular response to heat
regulation of protein import
chaperone-mediated autophagy translocation complex disassembly
regulation of transcription, DNA-templated
