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Invitrogen
HSD3B1/HSD3B2 Recombinant Rabbit Monoclonal Antibody (HL2307)
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HSD3B1/HSD3B2 Antibody (MA5-56747) in WB
Western Blot analysis of HSD3B1/HSD3B2 using HSD3B1/HSD3B2 Recombinant Monoclonal Antibody (Product # MA5-56747). Mouse adrenal gland and mouse muscle tissue extracts (50 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with HSD3B1/HSD3B2 antibody diluted at 1:1,000. A HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
产品信息
MA5-56747
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL2307
抗原
Recombinant fragment of human HSD3B2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
靶标信息
HSD3B1 and HSD3B2 (Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- and Steroid Delta-Isomerase 1 and 2) are genes that encode enzymes crucial for the biosynthesis of all classes of hormonal steroids, including glucocorticoids, mineralocorticoids, androgens, and estrogens. These enzymes catalyze the conversion of delta-5-3-beta-hydroxysteroids into delta-4-3-ketosteroids, a key step in the steroidogenesis pathway. HSD3B1 is predominantly expressed in the placenta and peripheral tissues, while HSD3B2 is mainly found in the adrenal glands and gonads. Mutations or dysregulation in these genes can lead to various disorders, such as congenital adrenal hyperplasia, which affects steroid hormone production and can result in a range of clinical symptoms from salt-wasting crises to ambiguous genitalia. Given their fundamental role in steroid metabolism, HSD3B1 and HSD3B2 are important targets for understanding and treating endocrine disorders and diseases related to steroid hormone imbalance.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD adrenal and gonadal type; 3-beta-HSD I; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; delta 5-delta 4-isomerase type II; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; progesterone reductase; short chain dehydrogenase/reductase family 11E, member 1; short chain dehydrogenase/reductase family 11E, member 2; Steroid Delta-isomerase; Trophoblast antigen FDO161G
基因别名: 3-beta-HSD I; 3BETAHSD; 3BH; D3Ertd383e; HSD3B; HSD3B1; HSD3B2; HSDB; HSDB3; HSDB3A; HSDB3B; I; SDR11E1; SDR11E2
UniProt ID: (Human) P14060, (Human) P26439, (Mouse) P24815, (Mouse) P26149
Entrez Gene ID: (Human) 3283, (Human) 3284, (Mouse) 15492, (Mouse) 15493
