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NeoBiotechnologies
HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) Monoclonal Antibody (LK2)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
3329-MSM2-P0
应用
建议稀释比
已发表文章
产品规格
种属反应
Bacteria,
Chicken,
Guinea pig,
Hamster,
Human,
Mouse,
Non-human primate,
Nematode,
Plant,
Rat,
Yeast
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
LK2
抗原
Recombinant human HSP60 protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
200 µg/mL
规格
20 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4°C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 60 kDa chaperonin; 60 kDa heat shock protein; a stress-inducible molecular chaperone which participates in protein folding; chaperonin; chaperonin (HSP60); Chaperonin 60; CPN60; epididymis secretory sperm binding protein; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock 60kDa protein 1 (chaperonin); heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_1; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_2; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_4; Heat shock protein; heat shock protein 1 (chaperonin); Heat shock protein 60; heat shock protein 60 (liver); heat shock protein 65; heat shock protein family D member 1; heat shock protein, 60 kDa; HSP; HSP-60; HSP-65; hsp60; Hsp60s1; Mitochondrial matrix protein P1; P1 protein; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; unnamed protein product
基因别名: 60kDa; CPN60; GROEL; HLD4; HSP-60; HSP-65; HSP60; HSP65; Hspd1-30p; HuCHA60; I79_011398; MIF4; MNA2; SPG13; YLR259C
UniProt ID: (Baker's yeast) P19882, (Chicken) Q5ZL72, (Human) P10809, (Mouse) P63038, (Chinese hamster) P18687, (Rat) P63039
Entrez Gene ID: (Baker's yeast) 850963, (Chicken) 424059, (Human) 3329, (Mouse) 15510, (Chinese hamster) 100689473, (Rat) 63868
nucleotide binding
DNA replication origin binding
single-stranded DNA binding
ATP binding
ATPase activity
unfolded protein binding
chaperone binding
ATP-dependent protein folding chaperone
lipopolysaccharide binding
p53 binding
double-stranded RNA binding
protein binding
high-density lipoprotein particle binding
isomerase activity
ubiquitin protein ligase binding
apolipoprotein A-I binding
RNA binding
enzyme binding
apolipoprotein binding
cysteine-type endopeptidase activator activity
macromolecular complex binding
modification-dependent protein binding
B cell cytokine production
MyD88-dependent toll-like receptor signaling pathway
positive regulation of T cell mediated immune response to tumor cell
protein folding
activation of cysteine-type endopeptidase activity involved in apoptotic process
apoptotic mitochondrial changes
response to cold
positive regulation of interferon-alpha production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
mitochondrial unfolded protein response
protein refolding
B cell proliferation
T cell activation
positive regulation of macrophage activation
negative regulation of apoptotic process
protein import into mitochondrial intermembrane space
isotype switching to IgG isotypes
protein stabilization
positive regulation of T cell activation
interaction with symbiont
cellular response to interleukin-7
response to hypoxia
positive regulation of cytokine production
response to ischemia
response to unfolded protein
response to xenobiotic stimulus
response to activity
response to lipopolysaccharide
positive regulation of tumor necrosis factor production
response to ATP
cellular response to heat
B cell activation
response to cocaine
response to hydrogen peroxide
negative regulation of neuron apoptotic process
response to estrogen
adhesion of symbiont to host
response to glucocorticoid
negative regulation of apoptotic process in bone marrow
negative regulation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
negative regulation of reactive oxygen species biosynthetic process
response to resveratrol
mitochondrial genome maintenance
'de novo' protein folding
chaperone-mediated protein complex assembly
protein maturation
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