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HSP70/HSC70/Heat shock protein 70 Polyclonal Antibody
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HSP70/HSC70/Heat shock protein 70 Antibody (AS09-592) in WB
5 µg of total protein from (1) cow muscle, (2) chicken muscle, (3) pig muscle, (4) rat liver, (5) salmon muscle, (6) seal muscle, (7) mummichog heat shock control, (8) mummichog heat shock post-24 hours, extracted with Protein Extraction Buffer, PEB (AS08 300), were separated on 4-12% Nu PAGE (Invitrogen) LDS-PAGE and blotted 1 h to PVDF. Blots were blocked immediately following transfer in 2% ECL Advance b... View More
产品信息
AS09-592
产品规格
种属反应
Amphibian,
Bovine,
C. elegans,
Chicken,
Fish,
Mycetozoan,
Plant,
Pig,
Protozoa,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
KLH-conjugated C-terminal synthetic peptide conserved in hsc/hsp70 sequences from a wide range of animal species.
偶联物
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 200 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana, Acanthamoeba castellanii (amoeba), Caenorhabditis elegans, salmon (Salmo salar), Dictyostelium discoideum, frog-heart, Frog-skeletal muscle, Frog-liver, rainbow trout (Oncorhynchus mykiss), cow, Chicken, pig, Rat, seal, mummichog
靶标信息
HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 70 kda heat shock protein-2; 70 kilodalton heat shock protein; ARABIDOPSIS HEAT SHOCK PROTEIN 70; ATHSP70; chaperone; heat shock 10kDa protein 1-like; heat shock 70 kD protein 1; heat shock 70 kD protein 2; heat shock 70 kD protein 3; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 2; Heat shock 70 kDa protein 3; Heat shock 70 kDa protein 4; heat shock 70kD protein 1B; heat shock 70kDa protein 1-like; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; heat shock 70kDa protein 2; heat shock 70kDa protein 3; heat shock 70kDa protein 4; Heat shock protein; Heat Shock Protein 70; heat shock protein 70-1; Heat shock protein 70-1l; Heat shock protein 70.2; heat shock protein alpha 2; Heat shock-related 70 kDa protein 2; heat-shock 70-kilodalton protein 1A; heat-shock 70-kilodalton protein 1B; HEL S 103; HSP; HSP70 1; HSP70 1B; HSP70 2; HSP70 AceyltK77; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70.1; HSP70.1/2; HSP70.1/HSP70.2; HSP70.2; HSP70.3; HSPA2; HSPA4; Hspa70; HST; Ischemia responsive 94 kDa protein; Testis-specific heat shock protein-related; testis-specific heat shock protein-related gene hst70
基因别名: CELE_C12C8.1; Hsp110; HSP70; HSP70-1; HSP70-2; HSP70-3; HSP72; HSPA1; HSPA1A; HSPA1B; HSPA1L; HSPA2; HSPA3; Hspa4; Hsph2; Hspt70; Hst70; Irp94
ATP binding
G-protein coupled receptor binding
protease binding
double-stranded RNA binding
protein binding
ATPase activity
enzyme binding
heat shock protein binding
ubiquitin protein ligase binding
ATPase activity, coupled
protein binding involved in protein folding
poly(A) RNA binding
protein N-terminus binding
NF-kappaB binding
unfolded protein binding
molecular_function
glycolipid binding
RNA polymerase II transcription factor binding
protein complex binding
activating transcription factor binding
nucleotide binding
misfolded protein binding
binding of sperm to zona pellucida
biological_process
protein refolding
spermatogenesis
response to heat
response to cold
cell differentiation
response to unfolded protein
determination of adult lifespan
endoplasmic reticulum unfolded protein response
cellular response to unfolded protein
IRE1-mediated unfolded protein response
chaperone mediated protein folding requiring cofactor
telomere maintenance
response to ischemia
DNA repair
mRNA catabolic process
negative regulation of cell proliferation
response to radiation
response to mechanical stimulus
regulation of cell death
neuron differentiation
negative regulation of cell growth
negative regulation of protein ubiquitination
cellular response to heat
negative regulation of apoptotic process
response to ethanol
positive regulation of erythrocyte differentiation
positive regulation of neuron differentiation
negative regulation of cell death
cellular heat acclimation
negative regulation of inclusion body assembly
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of protein targeting to mitochondrion
kidney development
negative regulation of protein phosphorylation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of protein binding
negative regulation of DNA binding
protein import into mitochondrial outer membrane
positive regulation of angiogenesis
chaperone-mediated protein complex assembly
positive regulation of microtubule nucleation
regulation of mitotic spindle assembly
positive regulation of protein phosphorylation
male meiosis
male meiosis I
multicellular organism development
spermatid development
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
synaptonemal complex disassembly
positive regulation of T cell mediated cytotoxicity
defense response
negative regulation of myeloid cell apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of vasoconstriction
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