Invitrogen

HSP90 Monoclonal Antibody (D7A), FITC

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说明书
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说明书
实验方案
问题与答案
技术支持
HSP90 Monoclonal Antibody (D7A), FITC

产品信息

MA5-45158

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:100,000
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-

免疫沉淀 (IP)

5 µg
-

Antibody Microarray (AM)

Assay-dependent
-
产品规格

种属反应

Bovine, Chicken, Human, Mouse, Pig, Rabbit, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

D7A

抗原

Full length protein HSP90 purified from chicken brain
查看免疫原

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱 spectra

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

9.1mM sodium bicarbonate/PBS, pH 7.2, with 640.91mM DMSO, 136.36mM ethanolamine

内含物

no preservative

保存条件

4°C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2931612

产品详细信息

2 µg/mL was sufficient for detection of HSP90 alpha in 20 µg of heat shocked HeLa cell lysate as well as in 100 ng of human HSP90 alpha protein by colorimetric immunoblot analysis using Goat Anti-Mouse IgG:HRP as the secondary.|Recognizes 90kDa.approximately Can isolate complexes of HSP90, Src kinase and cec37.

靶标信息

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 90-kDa heat shock protein; epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein 1, beta; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; heat shock protein 86; heat shock protein 90 beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class A member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP 90; HSP84; HSP86; hsp90 beta; HSP90-beta; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen

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基因别名: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; D6S182; EL52; HEL-S-65p; hsp4; HSP84; Hsp84-1; HSP86; Hsp86-1; Hsp89; HSP89A; HSP90; HSP90-BETA; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPC3; HSPCA; HSPCAL1; HSPCAL4; HSPCB; HSPN; LAP-2; LAP2

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UniProt ID: (Chicken) P11501, (Bovine) Q76LV2, (Pig) O02705, (Human) P07900, (Bovine) Q76LV1, (Rabbit) P30947, (Human) P08238, (Mouse) P07901, (Rat) P82995, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Chicken) 423463, (Bovine) 281832, (Pig) 397028, (Human) 3320, (Rabbit) 100338694, (Bovine) 767874, (Rabbit) 100358690, (Human) 3326, (Chicken) 396188, (Pig) 396742, (Mouse) 15519, (Rat) 299331, (Mouse) 15516, (Rat) 301252

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功能
ATP binding protein C-terminus binding ATPase activity nitric-oxide synthase regulator activity estrogen receptor binding TPR domain binding heat shock protein binding progesterone receptor binding identical protein binding virion binding unfolded protein binding chaperone binding Hsp90 protein binding disordered domain specific binding protein binding protein homodimerization activity nucleotide binding UTP binding CTP binding mRNA binding protein tyrosine kinase activity GTP binding sulfonylurea receptor binding protein kinase binding protein phosphatase binding MHC class II protein complex binding dATP binding histone deacetylase binding ion channel binding poly(A) RNA binding GTPase binding Rho GDP-dissociation inhibitor binding double-stranded RNA binding protein kinase regulator activity ubiquitin protein ligase binding peptide binding ATP-dependent protein binding protein binding involved in protein folding protein dimerization activity tau protein binding DNA polymerase binding histone methyltransferase binding kinase binding cadherin binding involved in cell-cell adhesion Hsp90 family chaperone
参与通路
protein folding positive regulation of cell proliferation response to heat response to cold response to organonitrogen compound response to organic cyclic compound response to progesterone cellular response to heat positive regulation of nitric oxide biosynthetic process response to antibiotic regulation of catalytic activity protein stabilization positive regulation of cell cycle G2/M phase transition G2/M transition of mitotic cell cycle neuron migration skeletal muscle contraction mitochondrial transport receptor-mediated endocytosis response to unfolded protein signal transduction response to salt stress positive regulation of lamellipodium assembly cardiac muscle cell apoptotic process peptidyl-tyrosine phosphorylation regulation of protein ubiquitination positive regulation of protein import into nucleus, translocation Fc-gamma receptor signaling pathway involved in phagocytosis ERBB2 signaling pathway protein refolding regulation of protein complex assembly protein unfolding response to estrogen protein import into mitochondrial outer membrane positive regulation of cell size vascular endothelial growth factor receptor signaling pathway regulation of nitric-oxide synthase activity chaperone-mediated protein complex assembly positive regulation of cardiac muscle contraction chaperone-mediated autophagy regulation of cellular response to heat placenta development telomere maintenance via telomerase virion attachment to host cell central nervous system neuron axonogenesis establishment of cell polarity positive regulation of transforming growth factor beta receptor signaling pathway negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process positive regulation of cell differentiation axon extension positive regulation of protein kinase B signaling positive regulation of telomerase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway negative regulation of cell cycle arrest cellular response to interleukin-4 fibril organization negative regulation of transforming growth factor beta activation positive regulation of cyclin-dependent protein kinase activity telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface positive regulation of protein binding negative regulation of neuron apoptotic process cellular response to organic cyclic compound positive regulation of protein serine/threonine kinase activity cell-cell adhesion nitric oxide biosynthetic process response to stress positive regulation of cytotoxic T cell differentiation
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