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Invitrogen

HSP90 Monoclonal Antibody (MBH90AB)

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4 篇参考文献
查看其他32个HSP90抗体

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产品信息

MA1-10372

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1 µg/mL
查看4篇已发表文章 4篇已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent
-
产品规格

种属反应

Bovine, Human, Mouse

已发表种属

Human, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

MBH90AB

抗原

Peptide corresponding to the sequence EEVHHGEEEVEC within N-terminal part of human Hsp90.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

PBS, pH 7.4, with 0.2% BSA

内含物

15mM sodium azide

保存条件

4°C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11155433

产品详细信息

This antibody recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta intracellular proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions.

靶标信息

HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 and mitochondria (Chen et al., 2005 ).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATHS83; AtHsp90-1; ATHSP90.1; F6N7.13; F6N7_13; Heat shock 84 kDa; Heat shock 86 kDa; heat shock 90 kDa protein; heat shock 90kD protein 1, alpha; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, alpha; heat shock protein 1, beta; HEAT SHOCK PROTEIN 81-1; HEAT SHOCK PROTEIN 83; HEAT SHOCK PROTEIN 90-1; heat shock protein 90.1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha (cytosolic), class B member 1; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90-beta; heat shock protein, 1; heat shock protein, 84 kDa 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; HSP; HSP 84; HSP 86; HSP81-1; HSP81.1; HSP83; HSP86; retinal degeneration slow protein; TSTA; Tumor-specific transplantation 84 kDa antigen; Tumor-specific transplantation 86 kDa antigen

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基因别名: 86kDa; 89kDa; 90kDa; AL022974; AL024080; AL024147; C81438; hsp4; Hsp84; Hsp84-1; Hsp86; Hsp86-1; Hsp89; Hsp90; HSP90A; HSP90AA1; HSP90AB1; HSPC3; HSPCA; HSPCB

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UniProt ID: (Bovine) Q76LV2, (Bovine) Q76LV1, (Mouse) P07901, (Mouse) P11499

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Entrez Gene ID: (Bovine) 281832, (Bovine) 767874, (Mouse) 15519, (Mouse) 15516

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功能
protein binding ATP binding ATPase activity nitric-oxide synthase regulator activity TPR domain binding protein homodimerization activity disordered domain specific binding double-stranded RNA binding protein kinase regulator activity protein kinase binding heat shock protein binding ubiquitin protein ligase binding peptide binding histone deacetylase binding ATP-dependent protein binding protein binding involved in protein folding protein dimerization activity tau protein binding DNA polymerase binding histone methyltransferase binding nucleotide binding UTP binding CTP binding mRNA binding GTP binding sulfonylurea receptor binding protein phosphatase binding MHC class II protein complex binding dATP binding identical protein binding ion channel binding poly(A) RNA binding GTPase binding Rho GDP-dissociation inhibitor binding unfolded protein binding kinase binding Hsp90 family chaperone
参与通路
response to heat response to cold positive regulation of nitric oxide biosynthetic process response to antibiotic regulation of catalytic activity placenta development telomere maintenance via telomerase virion attachment to host cell central nervous system neuron axonogenesis establishment of cell polarity positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of phosphoprotein phosphatase activity positive regulation of peptidyl-serine phosphorylation negative regulation of apoptotic process positive regulation of cell differentiation axon extension chaperone-mediated protein complex assembly positive regulation of protein kinase B signaling positive regulation of telomerase activity regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway negative regulation of cell cycle arrest cellular response to interleukin-4 fibril organization negative regulation of transforming growth factor beta activation positive regulation of cyclin-dependent protein kinase activity telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface neuron migration protein folding nitric oxide biosynthetic process response to stress response to unfolded protein positive regulation of lamellipodium assembly positive regulation of protein import into nucleus, translocation protein refolding protein import into mitochondrial outer membrane positive regulation of cytotoxic T cell differentiation positive regulation of cell size positive regulation of protein binding negative regulation of neuron apoptotic process positive regulation of protein serine/threonine kinase activity
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