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Rockland
HSP90 alpha Polyclonal Antibody
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HSP90 alpha Antibody (600-401-929) in WB
Western blot using Rocklands Affinity Purified anti-Hsp90 antibody shows detection of a band at ~90 kDa corresponding to Hsp90 in various lysate preparations (arrowhead). Cos7 transfected with mutant K294R Hsp90 (left two lanes), Cos7 transfected with wild type Hsp90 (middle two lanes) and empty vector Cos7 cells (right two lanes) were either treated with Trichostatin A (an HDAC inhibitor) or mock treated with DMSO only, as indicated. Transfected cells express either mutant or wt Hsp90 coupled to FlagTM tag. Anti-FlagTM immunoprecipitation... View More
产品信息
600-401-929
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Fruit fly,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 289-300 of human Hsp90 protein.
偶联物
形式
Liquid
浓度
1.24 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
内含物
0.01% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity-purified antibody is directed against human Hsp90 protein. A BLAST analysis was used to suggest cross reactivity with Hsp90 from human, mouse, rat, monkey, chicken and Drosophila based on 100% homology with the immunizing sequence. Reactivity of this antibody with Hsp90 from other species is unknown.
靶标信息
Heat shock proteins (HSP) are proteins that are expressed in response to various biological stress, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, and some kinases. It has been suggested that HSP90 is necessary to maintain structural integrity of at least some steroid receptors to allow for ligand binding during receptor activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis luminal secretory protein 52; epididymis secretory sperm binding protein Li 65p; Heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; Heat shock protein; heat shock protein 1, alpha; heat shock protein 86; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock protein 90kDa alpha family class A member 1; Heat shock protein family C member 1; Heat shock protein HSP 90-alpha; heat shock protein HSP90 alpha; heat shock protein, 1; heat shock protein, 86 kDa 1; heat shock protein, 89 kDa; Heat shock protein90; HSP; HSP 86; HSP 90 alpha; HSP86; LAP-2; Lipopolysaccharide-associated protein 2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38; TSTA; Tumor-specific transplantation 86 kDa antigen; unnamed protein product
基因别名: 86kDa; 89kDa; AL024080; AL024147; EL52; HEL-S-65p; Hsp103; hsp4; HSP86; Hsp86-1; Hsp89; HSP89A; Hsp90; HSP90A; HSP90AA1; HSP90N; HSPC1; HSPCA; HSPCAL1; HSPCAL4; HSPN; LAP-2; LAP2
UniProt ID: (Chicken) P11501, (Human) P07900, (Mouse) P07901, (Rat) P82995
Entrez Gene ID: (Chicken) 423463, (Human) 3320, (Mouse) 15519, (Rat) 299331
ATP binding
protein C-terminus binding
ATPase activity
nitric-oxide synthase regulator activity
estrogen receptor binding
TPR domain binding
heat shock protein binding
progesterone receptor binding
identical protein binding
virion binding
unfolded protein binding
chaperone binding
Hsp90 protein binding
disordered domain specific binding
nucleotide binding
UTP binding
CTP binding
RNA binding
mRNA binding
protein binding
GTP binding
hydrolase activity
sulfonylurea receptor binding
protein phosphatase binding
MHC class II protein complex binding
ubiquitin protein ligase binding
dATP binding
protein homodimerization activity
histone deacetylase binding
protein binding involved in protein folding
ion channel binding
tau protein binding
GTPase binding
Rho GDP-dissociation inhibitor binding
DNA polymerase binding
scaffold protein binding
ATP-dependent protein folding chaperone
enzyme-substrate adaptor activity
protein tyrosine kinase binding
protein kinase binding
poly(A) RNA binding
Hsp90 family chaperone
protein folding
positive regulation of cell proliferation
response to heat
response to cold
response to organonitrogen compound
response to organic cyclic compound
response to progesterone
cellular response to heat
positive regulation of nitric oxide biosynthetic process
response to antibiotic
regulation of catalytic activity
protein stabilization
positive regulation of cell cycle G2/M phase transition
neuron migration
activation of innate immune response
positive regulation of defense response to virus by host
skeletal muscle contraction
mitochondrial transport
response to unfolded protein
telomere maintenance via telomerase
response to xenobiotic stimulus
response to salt stress
positive regulation of lamellipodium assembly
cardiac muscle cell apoptotic process
protein import into mitochondrial matrix
regulation of protein ubiquitination
positive regulation of telomere maintenance via telomerase
positive regulation of protein polymerization
positive regulation of interferon-beta production
regulation of protein localization
protein refolding
response to cocaine
positive regulation of protein import into nucleus
regulation of apoptotic process
regulation of protein complex assembly
protein unfolding
response to estrogen
positive regulation of protein catabolic process
positive regulation of cell size
nitric oxide metabolic process
chaperone-mediated protein complex assembly
positive regulation of cardiac muscle contraction
chaperone-mediated autophagy
cellular response to virus
regulation of postsynaptic membrane neurotransmitter receptor levels
neurofibrillary tangle assembly
telomerase holoenzyme complex assembly
nitric oxide biosynthetic process
response to stress
positive regulation of protein import into nucleus, translocation
protein import into mitochondrial outer membrane
positive regulation of cytotoxic T cell differentiation
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