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Invitrogen

HSP90 beta Polyclonal Antibody

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29 篇参考文献
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HSP90 beta Polyclonal Antibody

产品信息

PA3-012

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:20,000
查看19篇已发表文章 19篇已发表文章

免疫组化 (IHC)

-
查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:100
-

免疫组化（冰冻） (IHC (F))

10 µg/mL
-

免疫细胞化学 (ICC/IF)

10-20 µg/mL
查看4篇已发表文章 4篇已发表文章

流式细胞分析 (Flow)

1-20 µg/mL
查看1篇已发表文章 1篇已发表文章

免疫沉淀 (IP)

2 µg
查看2篇已发表文章 2篇已发表文章
产品规格

种属反应

Human, Mouse, Non-human primate, Rat

已发表种属

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide corresponding to residues P(2) E E V H H G E E E V E(13) of mouse HSP84.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2121220

产品详细信息

PA3-012 detects heat shock protein 90 beta (HSP90) from human, monkey, mouse, and rat tissues and cells. This antibody does not detect HSP86.

PA3-012 has been successfully used in Western blot, immunohistochemistry, immunofluorescence, flow cytometry, and immunoprecipitation procedures. By Western blot, this antibody detects an ~84 kDa protein representing HSP84 from Hepa1 cell lysate. Immunofluorescence staining of HSP84 in Hepa1 cells with PA3-012 yields a pattern consistent with cytoplasmic staining. Immunoprecipitation experiments with this antibody suggest that HSP84 exists primarily as homodimers in Hepa 1 cells. Furthermore, the antibody is capable of precipitating HSP84 that is complexed with other proteins such as the aryl hydrocarbon (Ah) receptor.

The PA3-012 immunogen is a synthetic peptide corresponding to residues P(2) E E V H H G E E E V E(13) of mouse HSP84. The N-terminal regions of HSP84 and HSP86 show the largest difference in amino acid sequence.

靶标信息

Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 90kDa heat shock protein; Heat shock 84 kDa; heat shock 90kD protein 1, beta; heat shock 90kDa protein 1, beta; Heat shock protein; heat shock protein 1, beta; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; heat shock protein, 84 kDa 1; HSP; HSP 84; HSP 90; HSP84; HSP90-beta; retinal degeneration slow protein; RP1-302G2.1; TSTA; Tumor-specific transplantation 84 kDa antigen; unnamed protein product

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基因别名: 90kDa; AL022974; C81438; D6S182; HSP84; Hsp84-1; Hsp90; HSP90-BETA; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB

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UniProt ID: (Human) P08238, (Mouse) P11499, (Rat) P34058

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Entrez Gene ID: (Human) 3326, (Mouse) 15516, (Rat) 301252

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功能
nucleotide binding RNA binding double-stranded RNA binding protein binding ATP binding ATPase activity protein kinase regulator activity kinase binding protein kinase binding MHC class II protein complex binding nitric-oxide synthase regulator activity TPR domain binding heat shock protein binding ubiquitin protein ligase binding peptide binding identical protein binding protein homodimerization activity histone deacetylase binding ATP-dependent protein binding protein binding involved in protein folding cadherin binding protein dimerization activity tau protein binding unfolded protein binding DNA polymerase binding protein phosphatase activator activity disordered domain specific binding ATP-dependent protein folding chaperone receptor ligand inhibitor activity histone methyltransferase binding UTP binding CTP binding GTP binding sulfonylurea receptor binding dATP binding ion channel binding poly(A) RNA binding Hsp90 family chaperone
参与通路
placenta development protein folding response to unfolded protein telomere maintenance via telomerase virion attachment to host cell positive regulation of transforming growth factor beta receptor signaling pathway regulation of protein ubiquitination negative regulation of proteasomal ubiquitin-dependent protein catabolic process regulation of protein localization cellular response to heat negative regulation of apoptotic process positive regulation of nitric oxide biosynthetic process positive regulation of cell differentiation protein stabilization chaperone-mediated protein complex assembly regulation of cell cycle cellular response to interleukin-4 fibril organization negative regulation of proteasomal protein catabolic process telomerase holoenzyme complex assembly positive regulation of protein localization to cell surface response to stress positive regulation of protein binding positive regulation of protein import into nucleus, translocation negative regulation of neuron apoptotic process positive regulation of cell size positive regulation of protein serine/threonine kinase activity response to salt stress regulation of interferon-gamma-mediated signaling pathway regulation of type I interferon-mediated signaling pathway cellular response to organic cyclic compound
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