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NeoBiotechnologies
HSP90AB1 (Heat Shock Protein 90) Monoclonal Antibody (HSP90AB1, 3953)
产品信息
3326-MSM3-P1
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
HSP90AB1, 3953
抗原
Recombinant human HSP90AB1 protein fragment (around aa581-704)
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
靶标信息
Heat shock proteins (HSP) are expressed in response to various biological stresses, including heat. HSP90 is a 90 kDa protein that is induced under stress conditions, but is also one of the most abundant cellular proteins found under non-stress conditions. HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90 has been found to be associated with a number of other intracellular proteins, including steroid receptors, actin, tubulin, aryl hydrocarbon (Ah) receptor, and some kinases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Heat shock 84 kDa; heat shock 90kD protein 1, beta; Heat shock protein; heat shock protein 90 kDa; heat shock protein 90kDa alpha (cytosolic), class B member 1; heat shock protein 90kDa alpha family class B member 1; Heat shock protein family C member 3; Heat shock protein HSP 90-beta; HSP; HSP 84; HSP 90; HSP90-beta; RP1-302G2.1
基因别名: D6S182; HSP84; HSP90AB1; HSP90B; HSPC2; HSPC3; HSPCB
UniProt ID: (Human) P08238
Entrez Gene ID: (Human) 3326
UTP binding
CTP binding
double-stranded RNA binding
protein binding
ATP binding
GTP binding
sulfonylurea receptor binding
protein kinase regulator activity
kinase binding
protein kinase binding
MHC class II protein complex binding
nitric-oxide synthase regulator activity
TPR domain binding
dATP binding
histone deacetylase binding
ion channel binding
poly(A) RNA binding
unfolded protein binding
cadherin binding involved in cell-cell adhesion
Hsp90 family chaperone
placenta development
protein folding
response to unfolded protein
response to salt stress
virion attachment to host cell
regulation of protein ubiquitination
positive regulation of protein binding
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein import into nucleus, translocation
Fc-gamma receptor signaling pathway involved in phagocytosis
negative regulation of neuron apoptotic process
positive regulation of nitric oxide biosynthetic process
positive regulation of cell size
protein stabilization
regulation of interferon-gamma-mediated signaling pathway
regulation of type I interferon-mediated signaling pathway
cellular response to interleukin-4
cellular response to organic cyclic compound
positive regulation of protein serine/threonine kinase activity
fibril organization
cell-cell adhesion
regulation of cellular response to heat
