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Invitrogen
HTR1B Polyclonal Antibody
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产品信息
PA1-20650
产品规格
种属反应
Bat,
Bovine,
Dog,
Guinea pig,
Hamster,
Human,
Mouse,
Pig,
Rabbit,
Rat
已发表种属
C. elegans
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5HT1B Receptor.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-20650 detects 5-HT1B Receptor in human samples.
靶标信息
Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems. Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase. Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum. In situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-HT1B receptor; 5-HT1B serotonin receptor; 5-HT1D beta; 5-HT1D beta receptor; 5-HT1D subtype beta; 5-HT<1B> receptor; 5-HTR1B; 5-hydroxytryptamine (serotonin ) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B; 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled; 5-hydroxytryptamine 1B receptor; 5-Hydroxytryptamine 1D receptor subtype beta; 5-hydroxytryptamine receptor 1B; 5HT1B Receptor; S12; serotonin (5-hydroxytryptamine (5HT)) receptor type 1B; Serotonin 1D beta receptor; Serotonin receptor 1B
基因别名: 5-HT-1B; 5-HT-1D-beta; 5-HT1-LIKE; 5-HT1B; 5-HT1DB; 5ht1b; HTR1B; HTR1D2; HTR1DB; S12
G-protein coupled receptor internalization
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
adenylate cyclase-inhibiting serotonin receptor signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
chemical synaptic transmission
regulation of dopamine secretion
negative regulation of serotonin secretion
negative regulation of cAMP biosynthetic process
negative regulation of synaptic transmission, GABAergic
cellular response to drug
response to cocaine
vasoconstriction
drinking behavior
response to ethanol
bone remodeling
regulation of behavior
response to mineralocorticoid
negative regulation of synaptic transmission, glutamatergic
cellular response to alkaloid
cellular response to temperature stimulus
behavior
positive regulation of vascular smooth muscle cell proliferation
signal transduction
G-protein coupled receptor signaling pathway
serotonin receptor signaling pathway
feeding behavior
response to toxic substance
response to drug
